Size frequency distribution of the β-amyloid (aβ) deposits in dementia with Lewy bodies with associated Alzheimer’s disease pathology

Richard A. Armstrong, Nigel J. Cairns

Research output: Contribution to journalArticle

Abstract

The objective is to study β-amyloid (Aβ) deposition in dementia with Lewy bodies (DLB) with Alzheimer’s disease (AD) pathology (DLB/AD). The size frequency distributions of the Aβ deposits were studied and fitted by log-normal and power-law models. Patients were ten clinically and pathologically diagnosed DLB/AD cases. Size distributions had a single peak and were positively skewed and similar to those described in AD and Down’s syndrome. Size distributions had smaller means in DLB/AD than in AD. Log-normal and power-law models were fitted to the size distributions of the classic and diffuse deposits, respectively. Size distributions of Aβ deposits were similar in DLB/AD and AD. Size distributions of the diffuse deposits were fitted by a power-law model suggesting that aggregation/disaggregation of Aβ was the predominant factor, whereas the classic deposits were fitted by a log-normal distribution suggesting that surface diffusion was important in the pathogenesis of the classic deposits.
Original languageEnglish
Pages (from-to)471-477
Number of pages7
JournalNeurological Sciences
Volume30
Issue number6
DOIs
Publication statusPublished - 1 Dec 2009

Bibliographical note

© Springer-Verlag 2009

Keywords

  • dementia with Lewy bodies
  • Alzheimer’s disease
  • beta-Amyloid deposits
  • size frequency distributions
  • log-normal model
  • power-law model

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