Slowly Expanding Lesions in Pediatric-Onset Multiple Sclerosis

Valeria Pozzilli; Ferran Prados Carrasco; Neena Kim; Omar Abdel-Mannan; Riccardo Nistri; Philipp Goebl; Cheryl Hemingway; Asthik Biswas; Kshitij Mankad; Sniya Sudhakar; Amitav Parida; Sukhvir Wright; Evangeline Wassmer; Michael Eyre; Ming Lim; Thomas Rossor; Arman Eshaghi; Frederik Barkhof; Ermelinda De Meo; Olga Ciccarelli; Yael Hacohen

doi:10.1001/jamaneurol.2025.2619

Slowly Expanding Lesions in Pediatric-Onset Multiple Sclerosis

Valeria Pozzilli, Ferran Prados Carrasco, Neena Kim, Omar Abdel-Mannan, Riccardo Nistri, Philipp Goebl, Cheryl Hemingway, Asthik Biswas, Kshitij Mankad, Sniya Sudhakar, Amitav Parida, Sukhvir Wright, Evangeline Wassmer, Michael Eyre, Ming Lim, Thomas Rossor, Arman Eshaghi, Frederik Barkhof, Ermelinda De Meo, Olga CiccarelliYael Hacohen

Research output: Contribution to journal › Article › peer-review

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Abstract

Slowly expanding lesions (SELs) are chronic active lesions showing constant and concentric expansion, detectable through longitudinal MRI analysis.1 Over time, they exhibit progressive reduction in T1 signal intensity,2 reflecting axonal damage. Initially described in progressive multiple sclerosis (MS),3 SELs also occur in relapsing-remitting MS (RRMS) and have been associated with disability progression in adults.4,5 We investigated whether SELs in pediatric-onset MS are associated with greater disability, reduced brain volume growth, and elevated serum neurofilament light chain (NfL) levels.

Original language	English
Pages (from-to)	1197-1199
Number of pages	3
Journal	JAMA neurology
Volume	82
Issue number	11
Early online date	11 Aug 2025
DOIs	https://doi.org/10.1001/jamaneurol.2025.2619
Publication status	Published - 1 Nov 2025

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Pozzilli, V., Prados Carrasco, F., Kim, N., Abdel-Mannan, O., Nistri, R., Goebl, P., Hemingway, C., Biswas, A., Mankad, K., Sudhakar, S., Parida, A., Wright, S., Wassmer, E., Eyre, M., Lim, M., Rossor, T., Eshaghi, A., Barkhof, F., De Meo, E., ... Hacohen, Y. (2025). Slowly Expanding Lesions in Pediatric-Onset Multiple Sclerosis. JAMA neurology, 82(11), 1197-1199. https://doi.org/10.1001/jamaneurol.2025.2619

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title = "Slowly Expanding Lesions in Pediatric-Onset Multiple Sclerosis",

abstract = "Slowly expanding lesions (SELs) are chronic active lesions showing constant and concentric expansion, detectable through longitudinal MRI analysis.1 Over time, they exhibit progressive reduction in T1 signal intensity,2 reflecting axonal damage. Initially described in progressive multiple sclerosis (MS),3 SELs also occur in relapsing-remitting MS (RRMS) and have been associated with disability progression in adults.4,5 We investigated whether SELs in pediatric-onset MS are associated with greater disability, reduced brain volume growth, and elevated serum neurofilament light chain (NfL) levels.",

author = "Valeria Pozzilli and {Prados Carrasco}, Ferran and Neena Kim and Omar Abdel-Mannan and Riccardo Nistri and Philipp Goebl and Cheryl Hemingway and Asthik Biswas and Kshitij Mankad and Sniya Sudhakar and Amitav Parida and Sukhvir Wright and Evangeline Wassmer and Michael Eyre and Ming Lim and Thomas Rossor and Arman Eshaghi and Frederik Barkhof and {De Meo}, Ermelinda and Olga Ciccarelli and Yael Hacohen",

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doi = "10.1001/jamaneurol.2025.2619",

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Pozzilli, V, Prados Carrasco, F, Kim, N, Abdel-Mannan, O, Nistri, R, Goebl, P, Hemingway, C, Biswas, A, Mankad, K, Sudhakar, S, Parida, A, Wright, S , Wassmer, E, Eyre, M, Lim, M, Rossor, T, Eshaghi, A, Barkhof, F, De Meo, E, Ciccarelli, O & Hacohen, Y 2025, 'Slowly Expanding Lesions in Pediatric-Onset Multiple Sclerosis', JAMA neurology, vol. 82, no. 11, pp. 1197-1199. https://doi.org/10.1001/jamaneurol.2025.2619

TY - JOUR

T1 - Slowly Expanding Lesions in Pediatric-Onset Multiple Sclerosis

AU - Pozzilli, Valeria

AU - Prados Carrasco, Ferran

AU - Kim, Neena

AU - Abdel-Mannan, Omar

AU - Nistri, Riccardo

AU - Goebl, Philipp

AU - Hemingway, Cheryl

AU - Biswas, Asthik

AU - Mankad, Kshitij

AU - Sudhakar, Sniya

AU - Parida, Amitav

AU - Wright, Sukhvir

AU - Wassmer, Evangeline

AU - Eyre, Michael

AU - Lim, Ming

AU - Rossor, Thomas

AU - Eshaghi, Arman

AU - Barkhof, Frederik

AU - De Meo, Ermelinda

AU - Ciccarelli, Olga

AU - Hacohen, Yael

PY - 2025/11/1

Y1 - 2025/11/1

N2 - Slowly expanding lesions (SELs) are chronic active lesions showing constant and concentric expansion, detectable through longitudinal MRI analysis.1 Over time, they exhibit progressive reduction in T1 signal intensity,2 reflecting axonal damage. Initially described in progressive multiple sclerosis (MS),3 SELs also occur in relapsing-remitting MS (RRMS) and have been associated with disability progression in adults.4,5 We investigated whether SELs in pediatric-onset MS are associated with greater disability, reduced brain volume growth, and elevated serum neurofilament light chain (NfL) levels.

AB - Slowly expanding lesions (SELs) are chronic active lesions showing constant and concentric expansion, detectable through longitudinal MRI analysis.1 Over time, they exhibit progressive reduction in T1 signal intensity,2 reflecting axonal damage. Initially described in progressive multiple sclerosis (MS),3 SELs also occur in relapsing-remitting MS (RRMS) and have been associated with disability progression in adults.4,5 We investigated whether SELs in pediatric-onset MS are associated with greater disability, reduced brain volume growth, and elevated serum neurofilament light chain (NfL) levels.

UR - https://jamanetwork.com/journals/jamaneurology/article-abstract/2837587

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DO - 10.1001/jamaneurol.2025.2619

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SN - 2168-6149

VL - 82

SP - 1197

EP - 1199

JO - JAMA neurology

JF - JAMA neurology

IS - 11

ER -

Slowly Expanding Lesions in Pediatric-Onset Multiple Sclerosis

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