Small fiber neuropathy (SFN) is being recognized with increasing frequency in neuromuscular practice due to improved diagnostic techniques. Although there are some common etiologies, up to one‐third of cases are considered idiopathic. In recent years, several disorders have unexpectedly been reported in association with SFN, on clinical grounds and complementary investigations, including quantitative sensory testing, intraepidermal nerve fiber density and confocal corneal microscopy. Knowledge of these disorders is important in clinical practice as increased awareness enables prompt diagnosis of SFN in these settings and early optimal therapeutic management of affected patients. Furthermore, these new developments may lead to a better understanding of the pathophysiologic mechanisms underlying SFN in these different disorders as well as, in some cases, an expanded spectrum of affected organs and systems. This article reviews these reported associations, their possible pathophysiologic bases, and the potential resulting management implications.
Bibliographical noteThis is the peer reviewed version of the following article: Ghasemi, M. and Rajabally, Y.A. (2020), Small fiber neuropathy in unexpected clinical settings: a review. Muscle Nerve. Accepted Author Manuscript., which has been published in final form at https://doi.org/10.1002/mus.26808. This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.
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