TY - JOUR
T1 - Smooth muscle in tissue remodeling and hyper-reactivity
T2 - Airways and arteries
AU - Rydell-Törmänen, Kristina
AU - Risse, Paul André
AU - Kanabar, Varsha
AU - Bagchi, Rushita
AU - Czubryt, Michael P.
AU - Johnson, Jill R.
PY - 2013/2
Y1 - 2013/2
N2 - Smooth muscle comprises a key functional component of both the airways and their supporting vasculature. Dysfunction of smooth muscle contributes to and exacerbates a host of breathing-associated pathologies such as asthma, chronic obstructive pulmonary disease and pulmonary hypertension. These diseases may be marked by airway and/or vascular smooth muscle hypertrophy, proliferation and hyper-reactivity, and related conditions such as fibrosis and extracellular matrix remodeling. This review will focus on the contribution of airway or vascular smooth dysfunction to common airway diseases.
AB - Smooth muscle comprises a key functional component of both the airways and their supporting vasculature. Dysfunction of smooth muscle contributes to and exacerbates a host of breathing-associated pathologies such as asthma, chronic obstructive pulmonary disease and pulmonary hypertension. These diseases may be marked by airway and/or vascular smooth muscle hypertrophy, proliferation and hyper-reactivity, and related conditions such as fibrosis and extracellular matrix remodeling. This review will focus on the contribution of airway or vascular smooth dysfunction to common airway diseases.
KW - Airway smooth muscle
KW - Animal models
KW - Asthma
KW - Chronic obstructive pulmonary disease
KW - Pulmonary hypertension
KW - Vascular smooth muscle
UR - http://www.scopus.com/inward/record.url?scp=84873172114&partnerID=8YFLogxK
UR - https://www.sciencedirect.com/science/article/pii/S1094553912000533?via%3Dihub
U2 - 10.1016/j.pupt.2012.04.003
DO - 10.1016/j.pupt.2012.04.003
M3 - Article
C2 - 22561160
AN - SCOPUS:84873172114
SN - 1094-5539
VL - 26
SP - 13
EP - 23
JO - Pulmonary Pharmacology and Therapeutics
JF - Pulmonary Pharmacology and Therapeutics
IS - 1
ER -