Solid phase synthesis of a metronidazole oligonucleotide conjugate

Andrew J. Walsh; Michael L. Davis; William Fraser

doi:10.3390/11060486

Solid phase synthesis of a metronidazole oligonucleotide conjugate

Andrew J. Walsh, Michael L. Davis, William Fraser

Research output: Contribution to journal › Article › peer-review

Abstract

Direct, solid phase synthesis of an oligonucleotide conjugate of the antibiotic drug metronidazole was accomplished by the phosphoramidite method. Removal of protecting groups and cleavage from the controlled pore glass (CPG) solid support was successful using mild conditions (20% EtN in pyridine, then conc. NH (aq) at rt for 30 min) whereas standard conditions (conc. NH (aq) at 55°C for 16 h) cleaved the drug.

Original language	English
Pages (from-to)	486-495
Number of pages	10
Journal	Molecules
Volume	11
Issue number	6
DOIs	https://doi.org/10.3390/11060486
Publication status	Published - 23 Jun 2006

Bibliographical note

Creative commons : Attribution

Keywords

CPG
conjugate
metronidazole
oligonucleotide
phosphoramidite
solid phase

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10.3390/11060486

Solid phase synthesis of a metronidazole oligonucleotide conjugate
Creative commons : Attribution
Final published version, 75.6 KBLicence: CC BY 3.0

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keywords = "CPG, conjugate, metronidazole, oligonucleotide, phosphoramidite, solid phase",

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AU - Davis, Michael L.

AU - Fraser, William

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N2 - Direct, solid phase synthesis of an oligonucleotide conjugate of the antibiotic drug metronidazole was accomplished by the phosphoramidite method. Removal of protecting groups and cleavage from the controlled pore glass (CPG) solid support was successful using mild conditions (20% EtN in pyridine, then conc. NH (aq) at rt for 30 min) whereas standard conditions (conc. NH (aq) at 55°C for 16 h) cleaved the drug.

AB - Direct, solid phase synthesis of an oligonucleotide conjugate of the antibiotic drug metronidazole was accomplished by the phosphoramidite method. Removal of protecting groups and cleavage from the controlled pore glass (CPG) solid support was successful using mild conditions (20% EtN in pyridine, then conc. NH (aq) at rt for 30 min) whereas standard conditions (conc. NH (aq) at 55°C for 16 h) cleaved the drug.

KW - CPG

KW - conjugate

KW - metronidazole

KW - oligonucleotide

KW - phosphoramidite

KW - solid phase

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JO - Molecules

JF - Molecules

IS - 6

ER -

Solid phase synthesis of a metronidazole oligonucleotide conjugate

Abstract

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Keywords

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