Solid phase synthesis of a metronidazole oligonucleotide conjugate

Andrew J. Walsh, Michael L. Davis, William Fraser

Research output: Contribution to journalArticle

Abstract

Direct, solid phase synthesis of an oligonucleotide conjugate of the antibiotic drug metronidazole was accomplished by the phosphoramidite method. Removal of protecting groups and cleavage from the controlled pore glass (CPG) solid support was successful using mild conditions (20% EtN in pyridine, then conc. NH (aq) at rt for 30 min) whereas standard conditions (conc. NH (aq) at 55°C for 16 h) cleaved the drug.
Original languageEnglish
Pages (from-to)486-495
Number of pages10
JournalMolecules
Volume11
Issue number6
DOIs
Publication statusPublished - 23 Jun 2006

Bibliographical note

Creative commons : Attribution

Keywords

  • CPG
  • conjugate
  • metronidazole
  • oligonucleotide
  • phosphoramidite
  • solid phase

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