Solubilization of poorly soluble drugs: cyclodextrin-based formulations

Sachin S. Thakur; Harendra S. Parekh; Carl H. Schwable; Yong Gan; Defang Ouyang

doi:10.1002/9781118573983.ch3

Solubilization of poorly soluble drugs: cyclodextrin-based formulations

Sachin S. Thakur^*, Harendra S. Parekh, Carl H. Schwable, Yong Gan, Defang Ouyang

^*Corresponding author for this work

Research output: Chapter in Book/Published conference output › Chapter

Abstract

The delivery of therapeutics preferentially to target tissue remains a considerable barrier to achieving effective clinical outcomes; this ultimately requires a molecule to display both optimal hydrophilic and lipophilic properties. cyclodextrins (CDs) are successfully applied as drug solubilizing agents and they are now routinely employed for this purpose in a range of pharmaceutical formulations. The literature boasts a range of methods for the formation of drug-CD complexes. The solvents and processing parameters used may vary, but the commonly used techniques can be broadly divided into spray drying, freeze drying, slurry method, kneading, solid phase complexation, co-precipitation, and neutralization. A variety of techniques have been employed to confirm the formation and utility of CD complexes, namely thermo-analytical methods, differential scanning calorimetry (DSC) or differential thermal analysis (DTA), scanning electron microscopy (SEM), and transmission electron microscopy (TEM).

Original language	English
Title of host publication	Computational pharmaceutics
Subtitle of host publication	application of molecular modeling in drug delivery
Editors	Defang Ouyang, Sean C. Smith
Place of Publication	Chichester (UK)
Publisher	Wiley
Pages	31-51
Number of pages	21
ISBN (Electronic)	978-1-118-57398-3
ISBN (Print)	978-1-118-57399-0
DOIs	https://doi.org/10.1002/9781118573983.ch3
Publication status	Published - 29 Jun 2015

Publication series

Name	Advances in Pharmaceutical Technolog
Publisher	Wiley

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10.1002/9781118573983.ch3

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abstract = "The delivery of therapeutics preferentially to target tissue remains a considerable barrier to achieving effective clinical outcomes; this ultimately requires a molecule to display both optimal hydrophilic and lipophilic properties. cyclodextrins (CDs) are successfully applied as drug solubilizing agents and they are now routinely employed for this purpose in a range of pharmaceutical formulations. The literature boasts a range of methods for the formation of drug-CD complexes. The solvents and processing parameters used may vary, but the commonly used techniques can be broadly divided into spray drying, freeze drying, slurry method, kneading, solid phase complexation, co-precipitation, and neutralization. A variety of techniques have been employed to confirm the formation and utility of CD complexes, namely thermo-analytical methods, differential scanning calorimetry (DSC) or differential thermal analysis (DTA), scanning electron microscopy (SEM), and transmission electron microscopy (TEM).",

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Solubilization of poorly soluble drugs: cyclodextrin-based formulations. / Thakur, Sachin S.; Parekh, Harendra S.; Schwable, Carl H. et al.
Computational pharmaceutics: application of molecular modeling in drug delivery. ed. / Defang Ouyang; Sean C. Smith. Chichester (UK): Wiley, 2015. p. 31-51 (Advances in Pharmaceutical Technolog).

Research output: Chapter in Book/Published conference output › Chapter

TY - CHAP

T1 - Solubilization of poorly soluble drugs

T2 - cyclodextrin-based formulations

AU - Thakur, Sachin S.

AU - Parekh, Harendra S.

AU - Schwable, Carl H.

AU - Gan, Yong

AU - Ouyang, Defang

PY - 2015/6/29

Y1 - 2015/6/29

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AB - The delivery of therapeutics preferentially to target tissue remains a considerable barrier to achieving effective clinical outcomes; this ultimately requires a molecule to display both optimal hydrophilic and lipophilic properties. cyclodextrins (CDs) are successfully applied as drug solubilizing agents and they are now routinely employed for this purpose in a range of pharmaceutical formulations. The literature boasts a range of methods for the formation of drug-CD complexes. The solvents and processing parameters used may vary, but the commonly used techniques can be broadly divided into spray drying, freeze drying, slurry method, kneading, solid phase complexation, co-precipitation, and neutralization. A variety of techniques have been employed to confirm the formation and utility of CD complexes, namely thermo-analytical methods, differential scanning calorimetry (DSC) or differential thermal analysis (DTA), scanning electron microscopy (SEM), and transmission electron microscopy (TEM).

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T3 - Advances in Pharmaceutical Technolog

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BT - Computational pharmaceutics

A2 - Ouyang, Defang

A2 - Smith, Sean C.

PB - Wiley

CY - Chichester (UK)

ER -

Solubilization of poorly soluble drugs: cyclodextrin-based formulations

Abstract

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Computational pharmaceutics: application of molecular modeling in drug delivery

Introduction to computational pharmaceutics

Solid dispersion – a pragmatic method to improve the bioavailability of poorly soluble drugs

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