Solubilization of poorly soluble drugs: cyclodextrin-based formulations

Sachin S. Thakur*, Harendra S. Parekh, Carl H. Schwable, Yong Gan, Defang Ouyang

*Corresponding author for this work

Research output: Chapter in Book/Published conference outputChapter

Abstract

The delivery of therapeutics preferentially to target tissue remains a considerable barrier to achieving effective clinical outcomes; this ultimately requires a molecule to display both optimal hydrophilic and lipophilic properties. cyclodextrins (CDs) are successfully applied as drug solubilizing agents and they are now routinely employed for this purpose in a range of pharmaceutical formulations. The literature boasts a range of methods for the formation of drug-CD complexes. The solvents and processing parameters used may vary, but the commonly used techniques can be broadly divided into spray drying, freeze drying, slurry method, kneading, solid phase complexation, co-precipitation, and neutralization. A variety of techniques have been employed to confirm the formation and utility of CD complexes, namely thermo-analytical methods, differential scanning calorimetry (DSC) or differential thermal analysis (DTA), scanning electron microscopy (SEM), and transmission electron microscopy (TEM).
Original languageEnglish
Title of host publicationComputational pharmaceutics
Subtitle of host publicationapplication of molecular modeling in drug delivery
EditorsDefang Ouyang, Sean C. Smith
Place of PublicationChichester (UK)
PublisherWiley
Pages31-51
Number of pages21
ISBN (Electronic)978-1-118-57398-3
ISBN (Print)978-1-118-57399-0
DOIs
Publication statusPublished - 29 Jun 2015

Publication series

NameAdvances in Pharmaceutical Technolog
PublisherWiley

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  • Computational pharmaceutics: application of molecular modeling in drug delivery

    Ouyang, D. (ed.) & Smith, S. C. (ed.), 29 Jun 2015, Chichester (UK): Wiley. 340 p. (Advances in Pharmaceutical Technolog)

    Research output: Book/ReportEdited Book

  • Introduction to computational pharmaceutics

    Ouyang, D. & Smith, S. C., 29 Jun 2015, Computational pharmaceutics: application of molecular modeling in drug delivery. Ouyang, D. & Smith, S. C. (eds.). Chichester (UK): Wiley, p. 1-5 5 p. (Advances in Pharmaceutical Technolog).

    Research output: Chapter in Book/Published conference outputChapter

  • Solid dispersion – a pragmatic method to improve the bioavailability of poorly soluble drugs

    Ke, P., Qi, S., Ouyang, D. & Sadowski, G., 29 Jun 2015, Computational pharmaceutics: application of molecular modeling in drug delivery. Ouyang, D. & Smith, S. C. (eds.). Chichester (UK): Wiley, p. 81-100 20 p. (Advances in Pharmaceutical Technolog).

    Research output: Chapter in Book/Published conference outputChapter

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