Abstract
Original language | English |
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Pages (from-to) | 241-248 |
Number of pages | 8 |
Journal | Folia Neuropathologica |
Volume | 46 |
Issue number | 4 |
Publication status | Published - 2008 |
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Bibliographical note
Creative Commons Attribution Non-Commercial Share Alike International 4.0Keywords
- clustering
- frontal cortex
- blood vessels
- diffusion
- perivascular clearance
- spatial correlation
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Spatial correlations between beta-amyloid (A beta) deposits and blood vessels in familial Alzheimer's disease. / Armstrong, Richard A.
In: Folia Neuropathologica, Vol. 46, No. 4, 2008, p. 241-248.Research output: Contribution to journal › Article
TY - JOUR
T1 - Spatial correlations between beta-amyloid (A beta) deposits and blood vessels in familial Alzheimer's disease
AU - Armstrong, Richard A.
N1 - Creative Commons Attribution Non-Commercial Share Alike International 4.0
PY - 2008
Y1 - 2008
N2 - In sporadic Alzheimer’s disease (SAD), the classic (‘dense-cored’) ß-amyloid (Aß) deposits are aggregated around the larger blood vessels in the upper laminae of the cerebral cortex. To determine whether a similar relationship exists in familial AD (FAD), the spatial correlations between the diffuse, primitive, and classic ß-amyloid (Aß deposits and blood vessels were studied in ten FAD cases including cases linked to amyloid precursor protein (APP) and presenilin (PSEN) gene mutations and expressing apolipoprotein E (apo E) allele E4. Sections of frontal cortex were immunolabelled with antibodies against Aß and with collagen IV to reveal the Aß deposits and blood vessel profiles. In the FAD cases as a whole, Aßdeposits were distributed in clusters. There was a positive spatial correlation between the clusters of the diffuse Aßdeposits and the larger (>10 µm) and smaller diameter (<10 µm) blood vessels in one and three cases respectively. The primitive Aß deposits were spatially correlated with larger and smaller blood vessels each in four cases and the classic deposits in three and four cases respectively. Apo E genotype of the patient did not influence spatial correlation with blood vessels. Hence, spatial correlations between the classic deposits and larger diameter blood vessels were significantly less frequent in FAD compared with SAD. It was concluded that both Aß deposit morphology and AD subtype determine spatial correlations with blood vessels in AD.
AB - In sporadic Alzheimer’s disease (SAD), the classic (‘dense-cored’) ß-amyloid (Aß) deposits are aggregated around the larger blood vessels in the upper laminae of the cerebral cortex. To determine whether a similar relationship exists in familial AD (FAD), the spatial correlations between the diffuse, primitive, and classic ß-amyloid (Aß deposits and blood vessels were studied in ten FAD cases including cases linked to amyloid precursor protein (APP) and presenilin (PSEN) gene mutations and expressing apolipoprotein E (apo E) allele E4. Sections of frontal cortex were immunolabelled with antibodies against Aß and with collagen IV to reveal the Aß deposits and blood vessel profiles. In the FAD cases as a whole, Aßdeposits were distributed in clusters. There was a positive spatial correlation between the clusters of the diffuse Aßdeposits and the larger (>10 µm) and smaller diameter (<10 µm) blood vessels in one and three cases respectively. The primitive Aß deposits were spatially correlated with larger and smaller blood vessels each in four cases and the classic deposits in three and four cases respectively. Apo E genotype of the patient did not influence spatial correlation with blood vessels. Hence, spatial correlations between the classic deposits and larger diameter blood vessels were significantly less frequent in FAD compared with SAD. It was concluded that both Aß deposit morphology and AD subtype determine spatial correlations with blood vessels in AD.
KW - clustering
KW - frontal cortex
KW - blood vessels
KW - diffusion
KW - perivascular clearance
KW - spatial correlation
UR - https://www.termedia.pl/Spatial-correlations-between-946-amyloid-A-946-deposits-and-blood-vessels-in-familial-Alzheimer-8217-s-disease,20,11572,1,1.html
M3 - Article
VL - 46
SP - 241
EP - 248
JO - Folia Neuropathologica
JF - Folia Neuropathologica
SN - 1641-4640
IS - 4
ER -