Spatial correlations between beta-amyloid (A beta) deposits and blood vessels in familial Alzheimer's disease

Richard A. Armstrong

Research output: Contribution to journalArticle

Abstract

In sporadic Alzheimer’s disease (SAD), the classic (‘dense-cored’) ß-amyloid (Aß) deposits are aggregated around the larger blood vessels in the upper laminae of the cerebral cortex. To determine whether a similar relationship exists in familial AD (FAD), the spatial correlations between the diffuse, primitive, and classic ß-amyloid (Aß deposits and blood vessels were studied in ten FAD cases including cases linked to amyloid precursor protein (APP) and presenilin (PSEN) gene mutations and expressing apolipoprotein E (apo E) allele E4. Sections of frontal cortex were immunolabelled with antibodies against Aß and with collagen IV to reveal the Aß deposits and blood vessel profiles. In the FAD cases as a whole, Aßdeposits were distributed in clusters. There was a positive spatial correlation between the clusters of the diffuse Aßdeposits and the larger (>10 µm) and smaller diameter (<10 µm) blood vessels in one and three cases respectively. The primitive Aß deposits were spatially correlated with larger and smaller blood vessels each in four cases and the classic deposits in three and four cases respectively. Apo E genotype of the patient did not influence spatial correlation with blood vessels. Hence, spatial correlations between the classic deposits and larger diameter blood vessels were significantly less frequent in FAD compared with SAD. It was concluded that both Aß deposit morphology and AD subtype determine spatial correlations with blood vessels in AD.
Original languageEnglish
Pages (from-to)241-248
Number of pages8
JournalFolia Neuropathologica
Volume46
Issue number4
Publication statusPublished - 2008

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Amyloid
Blood Vessels
Alzheimer Disease
Amyloid Plaques
Apolipoproteins E
Presenilins
Amyloid beta-Protein Precursor
Frontal Lobe
Cerebral Cortex
Collagen
Alleles
Genotype
Mutation
Antibodies
Genes

Bibliographical note

Creative Commons Attribution Non-Commercial Share Alike International 4.0

Keywords

  • clustering
  • frontal cortex
  • blood vessels
  • diffusion
  • perivascular clearance
  • spatial correlation

Cite this

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abstract = "In sporadic Alzheimer’s disease (SAD), the classic (‘dense-cored’) {\ss}-amyloid (A{\ss}) deposits are aggregated around the larger blood vessels in the upper laminae of the cerebral cortex. To determine whether a similar relationship exists in familial AD (FAD), the spatial correlations between the diffuse, primitive, and classic {\ss}-amyloid (A{\ss} deposits and blood vessels were studied in ten FAD cases including cases linked to amyloid precursor protein (APP) and presenilin (PSEN) gene mutations and expressing apolipoprotein E (apo E) allele E4. Sections of frontal cortex were immunolabelled with antibodies against A{\ss} and with collagen IV to reveal the A{\ss} deposits and blood vessel profiles. In the FAD cases as a whole, A{\ss}deposits were distributed in clusters. There was a positive spatial correlation between the clusters of the diffuse A{\ss}deposits and the larger (>10 µm) and smaller diameter (<10 µm) blood vessels in one and three cases respectively. The primitive A{\ss} deposits were spatially correlated with larger and smaller blood vessels each in four cases and the classic deposits in three and four cases respectively. Apo E genotype of the patient did not influence spatial correlation with blood vessels. Hence, spatial correlations between the classic deposits and larger diameter blood vessels were significantly less frequent in FAD compared with SAD. It was concluded that both A{\ss} deposit morphology and AD subtype determine spatial correlations with blood vessels in AD.",
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Spatial correlations between beta-amyloid (A beta) deposits and blood vessels in familial Alzheimer's disease. / Armstrong, Richard A.

In: Folia Neuropathologica, Vol. 46, No. 4, 2008, p. 241-248.

Research output: Contribution to journalArticle

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