Spatial correlations between the vacuolation, prion protein (PrP sc) deposits and the cerebral blood vessels in sporadic Creutzfeldt-Jakob disease

Richard A. Armstrong

Research output: Contribution to journalArticle

Abstract

In the variant form of Creutzfeldt-Jakob disease (vCJD), 'florid' deposits of the protease resistant form of prion protein (PrPsc) were aggregated around the cerebral blood vessels suggesting the possibility that prions may spread into the brain via the cerebral micro circulation. The objective of the present study was to determine whether the pathology was spatially related to blood vessels in cases of sporadic CJD (sCJD), a disease without an iatrogenic etiology, and therefore, less likely to be caused by hematogenous spread. Hence, the spatial correlations between the vacuolation ('spongiform change'), PrPsc deposits, and the blood vessels were studied in immunolabeled sections of the cerebral cortex and cerebellum in eleven cases of the common M/M1 subtype of sCJD. Both the vacuolation and the PrPsc deposits were spatially correlated with the blood vessels; the PrPsc deposits being more focally distributed around the vessels than the vacuoles. The frequency of positive spatial correlations was similar in the different gyri of the cerebral cortex, in the upper and lower cortical laminae, and in the molecular layer of the cerebellum. It is hypothesised that the spatial correlation is attributable to factors associated with the blood vessels which promote the aggregation of PrPsc to form deposits rather than representing the hematogenous spread of the disease. The aggregated form of PrPsc then enhances cell death and may encourages the development of vacuolation in the vicinity of the blood vessels.

Original languageEnglish
Pages (from-to)239-245
Number of pages7
JournalCurrent Neurovascular Research
Volume6
Issue number4
DOIs
Publication statusPublished - 31 Dec 2009

Fingerprint

Blood Vessels
Cerebral Cortex
Cerebellum
Cerebrovascular Circulation
Iatrogenic Disease
Creutzfeldt-Jakob Syndrome
Prions
Vacuoles
Sporadic Creutzfeldt-Jakob Disease
Prion Proteins
Peptide Hydrolases
Cell Death
Pathology
Brain
Acquired CJD

Keywords

  • cerebral blood vessels
  • correlation
  • M/M1 subtype
  • prion protein (PrP) deposits
  • sporadic Creutzfeldt-Jakob disease (sCJD)
  • vacuolation

Cite this

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Spatial correlations between the vacuolation, prion protein (PrP sc) deposits and the cerebral blood vessels in sporadic Creutzfeldt-Jakob disease. / Armstrong, Richard A.

In: Current Neurovascular Research, Vol. 6, No. 4, 31.12.2009, p. 239-245.

Research output: Contribution to journalArticle

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