Spatial topography of the neurofibrillary tangles in cortical and subcortical regions in progressive supranuclear palsy

Richard A. Armstrong*, Peter L. Lantos, Nigel J. Cairns

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

Objective: To study the topography of neurofibrillary tangles (NFT) in cortical and subcortical areas in progressive supranuclear palsy (PSP). Methods: Pattern analysis was carried out on tau-positive NFT in eight PSP cases. Results: Of the areas studied, NFT were randomly distributed in 68%, regularly distributed in 3%, and clustered in 29%. A regular distribution of clusters was more frequent in cortical than subcortical areas. Conclusion: NFT topography in subcortical areas was similar to inclusions in the synucleinopathy multiple system atrophy (MSA) but in cortical areas was comparable to other tauopathies. © 2006 Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)50-54
Number of pages5
JournalParkinsonism and Related Disorders
Volume13
Issue number1
DOIs
Publication statusPublished - Feb 2007

Keywords

  • cerebral cortex
  • cortico-cortical pathways
  • neurofibrillary tangles (NFT)
  • progressive supranuclear palsy (PSP)
  • spatial pattern
  • subcortical regions

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