Abstract
Objective: To study the topography of neurofibrillary tangles (NFT) in cortical and subcortical areas in progressive supranuclear palsy (PSP). Methods: Pattern analysis was carried out on tau-positive NFT in eight PSP cases. Results: Of the areas studied, NFT were randomly distributed in 68%, regularly distributed in 3%, and clustered in 29%. A regular distribution of clusters was more frequent in cortical than subcortical areas. Conclusion: NFT topography in subcortical areas was similar to inclusions in the synucleinopathy multiple system atrophy (MSA) but in cortical areas was comparable to other tauopathies. © 2006 Elsevier Ltd. All rights reserved.
| Original language | English |
|---|---|
| Pages (from-to) | 50-54 |
| Number of pages | 5 |
| Journal | Parkinsonism and Related Disorders |
| Volume | 13 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Feb 2007 |
Keywords
- cerebral cortex
- cortico-cortical pathways
- neurofibrillary tangles (NFT)
- progressive supranuclear palsy (PSP)
- spatial pattern
- subcortical regions
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