Specific lipidome signatures in central nervous system from methionine-restricted mice

Mariona Jové, Victòria Ayala, Omar Ramírez-Núñez, Alba Naudí, Rosanna Cabré, Corinne M Spickett, Manuel Portero-Otin, Reinald Pamplona

Research output: Contribution to journalArticle

Abstract

Membrane lipid composition is an important correlate of the rate of aging of animals. Dietary methionine restriction (MetR) increases lifespan in rodents. The underlying mechanisms have not been elucidated but could include changes in tissue lipidomes. In this work, we demonstrate that 80% MetR in mice induces marked changes in the brain, spinal cord, and liver lipidomes. Further, at least 50% of the lipids changed are common in the brain and spinal cord but not in the liver, suggesting a nervous system-specific lipidomic profile of MetR. The differentially expressed lipids includes (a) specific phospholipid species, which could reflect adaptive membrane responses, (b) sphingolipids, which could lead to changes in ceramide signaling pathways, and (c) the physiologically redox-relevant ubiquinone 9, indicating adaptations in phase II antioxidant response metabolism. In addition, specific oxidation products derived from cholesterol, phosphatidylcholine, and phosphatidylethanolamine were significantly decreased in the brain, spinal cord, and liver from MetR mice. These results demonstrate the importance of adaptive responses of membrane lipids leading to increased stress resistance as a major mechanistic contributor to the lowered rate of aging in MetR mice. © 2013 American Chemical Society.

LanguageEnglish
Pages2679-2689
Number of pages11
JournalJournal of Proteome Research
Volume12
Issue number6
DOIs
Publication statusE-pub ahead of print - 14 Apr 2013

Fingerprint

Neurology
Methionine
Central Nervous System
Liver
Brain
Spinal Cord
Membrane Lipids
Aging of materials
Lipids
Sphingolipids
Ceramides
Phosphatidylcholines
Metabolism
Nervous System
Oxidation-Reduction
Rodentia
Phospholipids
Animals
Antioxidants
Cholesterol

Keywords

  • free radicals
  • membrane unsaturation
  • mitochondria
  • phase-II antioxidants
  • phospholipids oxidation
  • rate of aging

Cite this

Jové, M., Ayala, V., Ramírez-Núñez, O., Naudí, A., Cabré, R., Spickett, C. M., ... Pamplona, R. (2013). Specific lipidome signatures in central nervous system from methionine-restricted mice. Journal of Proteome Research, 12(6), 2679-2689. https://doi.org/10.1021/pr400064a
Jové, Mariona ; Ayala, Victòria ; Ramírez-Núñez, Omar ; Naudí, Alba ; Cabré, Rosanna ; Spickett, Corinne M ; Portero-Otin, Manuel ; Pamplona, Reinald. / Specific lipidome signatures in central nervous system from methionine-restricted mice. In: Journal of Proteome Research. 2013 ; Vol. 12, No. 6. pp. 2679-2689.
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Jové, M, Ayala, V, Ramírez-Núñez, O, Naudí, A, Cabré, R, Spickett, CM, Portero-Otin, M & Pamplona, R 2013, 'Specific lipidome signatures in central nervous system from methionine-restricted mice' Journal of Proteome Research, vol. 12, no. 6, pp. 2679-2689. https://doi.org/10.1021/pr400064a

Specific lipidome signatures in central nervous system from methionine-restricted mice. / Jové, Mariona; Ayala, Victòria; Ramírez-Núñez, Omar; Naudí, Alba; Cabré, Rosanna; Spickett, Corinne M; Portero-Otin, Manuel; Pamplona, Reinald.

In: Journal of Proteome Research, Vol. 12, No. 6, 14.04.2013, p. 2679-2689.

Research output: Contribution to journalArticle

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T1 - Specific lipidome signatures in central nervous system from methionine-restricted mice

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