Spinal CX3CL1/CX3CR1 may not directly participate in the development of morphine tolerance in rats

Yawen Peng, Genhua Guo, Bin Shu, Daiqiang Liu, Peng Su, Xuming Zhang, Feng Gao*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

CX3CL1 (fractalkine), the sole member of chemokine CX3C family, is implicated in inflammatory and neuropathic pain via activating its receptor CX3CR1 on neural cells in spinal cord. However, it has not been fully elucidated whether CX3CL1 or CX3CR1 contributes to the development of morphine tolerance. In this study, we found that chronic morphine exposure did not alter the expressions of CX3CL1 and CX3CR1 in spinal cord. And neither exogenous CX3CL1 nor CX3CR1 inhibitor could affect the development of morphine tolerance. The cellular localizations of spinal CX3CL1 and CX3CR1 changed from neuron and microglia, respectively, to all the neural cells during the development of morphine tolerance. A microarray profiling revealed that 15 members of chemokine family excluding CX3CL1 and CX3CR1 were up-regulated in morphine-treated rats. Our study provides evidence that spinal CX3CL1 and CX3CR1 may not be involved in the development of morphine tolerance directly.

Original languageEnglish
Pages (from-to)3254–3267
JournalNeurochemical Research
Volume42
Issue number11
Early online date3 Aug 2017
DOIs
Publication statusPublished - 1 Nov 2017

Bibliographical note

The final publication is available at Springer via http://dx.doi.org/10.1007/s11064-017-2364-z

Keywords

  • chemokine
  • CX3CL1
  • CX3CR1
  • morphine tolerance

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