Spontaneous mirror symmetry breaking from recycling in enantioselective polymerization

David Hochberg, Celia Blanco, Michael Stich*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

A key challenge for origin of life research is understanding how the homochirality of extant biological systems may have emerged during the abiotic phase of chemical evolution. Living systems depend on bio-macromolecules made from chiral building blocks and a crucial question is the relationship of polymerization with the emergence of homochirality. We present a reaction scheme demonstrating how spontaneous mirror symmetry breaking (SMSB) can be achieved in enantioselective polymerization without chiral inhibition and without autocatalysis. The model is based on nucleated cooperative polymerization: nucleation, elongation, dissociation, fusion and fragmentation and monomer racemization. These are micro-reversible processes subject to constraints dictated by chemical thermodynamics. To maintain this closed system out of equilibrium, we model an external energy source which induces the irreversible breakage of the longest polymers in the system. Simulations reveal that SMSB can be achieved starting from the tiny intrinsic statistical fluctuations about the idealized mirror symmetric composition.

Original languageEnglish
Title of host publicationSEMA SIMAI Springer Series
EditorsJ. Carballido-Landeira, B. Escribano
PublisherSpringer International Publishing AG
Pages39-57
Number of pages19
ISBN (Electronic)978-3-030-16585-7
ISBN (Print)978-3-030-16584-0
DOIs
Publication statusE-pub ahead of print - 30 Apr 2019

Publication series

NameSEMA SIMAI Springer Series
Volume20
ISSN (Print)2199-3041
ISSN (Electronic)2199-305X

Fingerprint

Mirror Symmetry
Recycling
Polymerization
recycling
Symmetry Breaking
polymerization
broken symmetry
Mirrors
mirrors
Chemical Evolution
Origin of Life
autocatalysis
Living Systems
Breakage
closed loop systems
Equilibrium Model
chemical evolution
Biological systems
energy sources
Elongation

Cite this

Hochberg, D., Blanco, C., & Stich, M. (2019). Spontaneous mirror symmetry breaking from recycling in enantioselective polymerization. In J. Carballido-Landeira, & B. Escribano (Eds.), SEMA SIMAI Springer Series (pp. 39-57). (SEMA SIMAI Springer Series; Vol. 20). Springer International Publishing AG. https://doi.org/10.1007/978-3-030-16585-7_3
Hochberg, David ; Blanco, Celia ; Stich, Michael. / Spontaneous mirror symmetry breaking from recycling in enantioselective polymerization. SEMA SIMAI Springer Series. editor / J. Carballido-Landeira ; B. Escribano. Springer International Publishing AG, 2019. pp. 39-57 (SEMA SIMAI Springer Series).
@inbook{e1c75410beaf493ab20b0a1bd3f93c25,
title = "Spontaneous mirror symmetry breaking from recycling in enantioselective polymerization",
abstract = "A key challenge for origin of life research is understanding how the homochirality of extant biological systems may have emerged during the abiotic phase of chemical evolution. Living systems depend on bio-macromolecules made from chiral building blocks and a crucial question is the relationship of polymerization with the emergence of homochirality. We present a reaction scheme demonstrating how spontaneous mirror symmetry breaking (SMSB) can be achieved in enantioselective polymerization without chiral inhibition and without autocatalysis. The model is based on nucleated cooperative polymerization: nucleation, elongation, dissociation, fusion and fragmentation and monomer racemization. These are micro-reversible processes subject to constraints dictated by chemical thermodynamics. To maintain this closed system out of equilibrium, we model an external energy source which induces the irreversible breakage of the longest polymers in the system. Simulations reveal that SMSB can be achieved starting from the tiny intrinsic statistical fluctuations about the idealized mirror symmetric composition.",
author = "David Hochberg and Celia Blanco and Michael Stich",
year = "2019",
month = "4",
day = "30",
doi = "10.1007/978-3-030-16585-7_3",
language = "English",
isbn = "978-3-030-16584-0",
series = "SEMA SIMAI Springer Series",
publisher = "Springer International Publishing AG",
pages = "39--57",
editor = "J. Carballido-Landeira and B. Escribano",
booktitle = "SEMA SIMAI Springer Series",
address = "Switzerland",

}

Hochberg, D, Blanco, C & Stich, M 2019, Spontaneous mirror symmetry breaking from recycling in enantioselective polymerization. in J Carballido-Landeira & B Escribano (eds), SEMA SIMAI Springer Series. SEMA SIMAI Springer Series, vol. 20, Springer International Publishing AG, pp. 39-57. https://doi.org/10.1007/978-3-030-16585-7_3

Spontaneous mirror symmetry breaking from recycling in enantioselective polymerization. / Hochberg, David; Blanco, Celia; Stich, Michael.

SEMA SIMAI Springer Series. ed. / J. Carballido-Landeira; B. Escribano. Springer International Publishing AG, 2019. p. 39-57 (SEMA SIMAI Springer Series; Vol. 20).

Research output: Chapter in Book/Report/Conference proceedingChapter

TY - CHAP

T1 - Spontaneous mirror symmetry breaking from recycling in enantioselective polymerization

AU - Hochberg, David

AU - Blanco, Celia

AU - Stich, Michael

PY - 2019/4/30

Y1 - 2019/4/30

N2 - A key challenge for origin of life research is understanding how the homochirality of extant biological systems may have emerged during the abiotic phase of chemical evolution. Living systems depend on bio-macromolecules made from chiral building blocks and a crucial question is the relationship of polymerization with the emergence of homochirality. We present a reaction scheme demonstrating how spontaneous mirror symmetry breaking (SMSB) can be achieved in enantioselective polymerization without chiral inhibition and without autocatalysis. The model is based on nucleated cooperative polymerization: nucleation, elongation, dissociation, fusion and fragmentation and monomer racemization. These are micro-reversible processes subject to constraints dictated by chemical thermodynamics. To maintain this closed system out of equilibrium, we model an external energy source which induces the irreversible breakage of the longest polymers in the system. Simulations reveal that SMSB can be achieved starting from the tiny intrinsic statistical fluctuations about the idealized mirror symmetric composition.

AB - A key challenge for origin of life research is understanding how the homochirality of extant biological systems may have emerged during the abiotic phase of chemical evolution. Living systems depend on bio-macromolecules made from chiral building blocks and a crucial question is the relationship of polymerization with the emergence of homochirality. We present a reaction scheme demonstrating how spontaneous mirror symmetry breaking (SMSB) can be achieved in enantioselective polymerization without chiral inhibition and without autocatalysis. The model is based on nucleated cooperative polymerization: nucleation, elongation, dissociation, fusion and fragmentation and monomer racemization. These are micro-reversible processes subject to constraints dictated by chemical thermodynamics. To maintain this closed system out of equilibrium, we model an external energy source which induces the irreversible breakage of the longest polymers in the system. Simulations reveal that SMSB can be achieved starting from the tiny intrinsic statistical fluctuations about the idealized mirror symmetric composition.

UR - http://www.scopus.com/inward/record.url?scp=85065409438&partnerID=8YFLogxK

UR - https://link.springer.com/chapter/10.1007%2F978-3-030-16585-7_3

U2 - 10.1007/978-3-030-16585-7_3

DO - 10.1007/978-3-030-16585-7_3

M3 - Chapter

AN - SCOPUS:85065409438

SN - 978-3-030-16584-0

T3 - SEMA SIMAI Springer Series

SP - 39

EP - 57

BT - SEMA SIMAI Springer Series

A2 - Carballido-Landeira, J.

A2 - Escribano, B.

PB - Springer International Publishing AG

ER -

Hochberg D, Blanco C, Stich M. Spontaneous mirror symmetry breaking from recycling in enantioselective polymerization. In Carballido-Landeira J, Escribano B, editors, SEMA SIMAI Springer Series. Springer International Publishing AG. 2019. p. 39-57. (SEMA SIMAI Springer Series). https://doi.org/10.1007/978-3-030-16585-7_3