Structure and function of the entorhinal cortex with special reference to neurodegenerative disease

Richard A. Armstrong

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Abstract

The entorhinal cortex (EC) comprises the anterior portion of the parahippocampal gyrus (PHG) and constitutes an important part of the medial temporal lobe (MTL) of the brain. The EC is involved in a variety of brain functions including the analysis of olfactory information, various types of memory, and the final integration of sensory data before being transmitted to the hippocampus (HC) via the perforant path. Significant pathology occurs in the EC and HC in neurodegenerative disease and therefore, these regions may be involved in the development of the cognitive deficits characteristics of these disorders. Based on the severity of pathological change in the EC, neurodegenerative disorders can be divided into three groups: (1) those in which high densities of neuronal cytoplasmic inclusions (NCI) and/or extracellular protein deposits occur in the EC, e.g., Alzheimer’s disease (AD), Down’s syndrome (DS), and sporadic Creutzfeldt-Jakob disease (sCJD), (2) those with moderate densities of NCI and/or extracellular protein deposits in the EC, e.g., argyrophilic grain disease (AGD), dementia with Lewy bodies (DLB), progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), Pick’s disease (PiD), neuronal intermediate filament inclusion disease (NIFID), and variant CJD (vCJD), and (3) those in which there is relatively little pathology in the EC, e.g., Parkinson’s disease dementia (PD-Dem), frontotemporal lobar degeneration with TDP-43-immunoreactive inclusions (FTLD-TDP), and multiple system atrophy (MSA). Hence, EC pathology varies significantly among disorders which could contribute to differences in the development of memory deficits among dementias. Pathological differences among disorders could reflect either differential vulnerability of the EC to specific molecular pathologies or variation in the degree of spread of pathological proteins among regions of the MTL.
Original languageEnglish
Title of host publicationHorizons in neurological research
EditorsAndres Costa, Eugenio Villalba
Place of PublicationHauppage, NJ (US)
PublisherNova science
Pages59-82
Number of pages23
ISBN (Electronic)978-1-63484-326-3
ISBN (Print)978-1-63484-325-6
Publication statusPublished - 2016

Publication series

NameHorizons in Neuroscience Research
PublisherNova
Volume24

Fingerprint

Entorhinal Cortex
Neurodegenerative Diseases
Inclusion Bodies
Temporal Lobe
Pathology
Dementia
Hippocampus
Pick Disease of the Brain
Frontotemporal Lobar Degeneration
Perforant Pathway
Progressive Supranuclear Palsy
Multiple System Atrophy
Lewy Body Disease
Frontotemporal Dementia
Parahippocampal Gyrus
Proteins
Intermediate Filaments
Molecular Pathology
Memory Disorders
Cytomegalovirus Infections

Keywords

  • entorhinal cortex
  • perforant path
  • hippocampal formation
  • spatial memory
  • neurodegenerative disease

Cite this

Armstrong, R. A. (2016). Structure and function of the entorhinal cortex with special reference to neurodegenerative disease. In A. Costa, & E. Villalba (Eds.), Horizons in neurological research (pp. 59-82). (Horizons in Neuroscience Research; Vol. 24). Hauppage, NJ (US): Nova science.
Armstrong, Richard A. / Structure and function of the entorhinal cortex with special reference to neurodegenerative disease. Horizons in neurological research. editor / Andres Costa ; Eugenio Villalba. Hauppage, NJ (US) : Nova science, 2016. pp. 59-82 (Horizons in Neuroscience Research).
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Armstrong, RA 2016, Structure and function of the entorhinal cortex with special reference to neurodegenerative disease. in A Costa & E Villalba (eds), Horizons in neurological research. Horizons in Neuroscience Research, vol. 24, Nova science, Hauppage, NJ (US), pp. 59-82.

Structure and function of the entorhinal cortex with special reference to neurodegenerative disease. / Armstrong, Richard A.

Horizons in neurological research. ed. / Andres Costa; Eugenio Villalba. Hauppage, NJ (US) : Nova science, 2016. p. 59-82 (Horizons in Neuroscience Research; Vol. 24).

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

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Armstrong RA. Structure and function of the entorhinal cortex with special reference to neurodegenerative disease. In Costa A, Villalba E, editors, Horizons in neurological research. Hauppage, NJ (US): Nova science. 2016. p. 59-82. (Horizons in Neuroscience Research).