Submicron scale tissue multifractal anisotropy in polarized laser light scattering

Nandan Kumar Das, Rajib Dey, Semanti Chakraborty, Prasanta K. Panigrahi, Igor Meglinski, Nirmalya Ghosh

Research output: Contribution to journalArticlepeer-review


The spatial fluctuations of the refractive index within biological tissues exhibit multifractal anisotropy, leaving its signature as a spectral linear diattenuation of scattered polarized light. The multifractal anisotropy has been quantitatively assessed by the processing of relevant Mueller matrix elements in the Fourier domain, utilizing the Born approximation and subsequent multifractal analysis. The differential scaling exponent and width of the singularity spectrum appear to be highly sensitive to the structural multifractal anisotropy at the micron/sub-micron length scales. An immediate practical use of these multifractal anisotropy parameters was explored for non-invasive screening of cervical precancerous alterations ex vivo, with the indication of a strong potential for clinical diagnostic purposes.

Original languageEnglish
Article number035601
JournalLaser Physics Letters
Issue number3
Publication statusPublished - 1 Feb 2018

Bibliographical note

©2018 IOP Publishing Ltd.


  • other optical properties
  • polarization
  • scattering
  • spectroscopy
  • tissue characterization
  • tissue diagnostics


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