Abstract
The spatial fluctuations of the refractive index within biological tissues exhibit multifractal anisotropy, leaving its signature as a spectral linear diattenuation of scattered polarized light. The multifractal anisotropy has been quantitatively assessed by the processing of relevant Mueller matrix elements in the Fourier domain, utilizing the Born approximation and subsequent multifractal analysis. The differential scaling exponent and width of the singularity spectrum appear to be highly sensitive to the structural multifractal anisotropy at the micron/sub-micron length scales. An immediate practical use of these multifractal anisotropy parameters was explored for non-invasive screening of cervical precancerous alterations ex vivo, with the indication of a strong potential for clinical diagnostic purposes.
| Original language | English |
|---|---|
| Article number | 035601 |
| Journal | Laser Physics Letters |
| Volume | 15 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 1 Feb 2018 |
Bibliographical note
©2018 IOP Publishing Ltd.Funding
This work was supported by IISER-Kolkata, an autonomous institute funded by MHRD, Government of India. We would also like to acknowledge BRNS-DAE, Government of India for funding. The authors thank Dr Asha Agarwal, G.S.V.M. Medical College and Hospital, Kanpur, for providing the histopathologically characterized tissue samples. Professor Meglinski acknowledges the support provided by the ITEE Faculty of the University of Oulu, Finland, National Research Tomsk State University Academic D.I. Mendeleev Fund Program, and the partial support of the Russian Science Foundation (Grant No.: 15-14-10008).
Keywords
- other optical properties
- polarization
- scattering
- spectroscopy
- tissue characterization
- tissue diagnostics