Sulphonated biomaterials as glycosaminoglycan mimics in wound healing

Brian J. Tighe, Aisling M. Mann*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

This chapter considers the available evidence and underlying physicochemical principles that support the proposition that a biomimetic wound dressing based on glycosaminoglycan models offers a potential means of influencing wound bioactivity. Available evidence showing advantages in wound healing for experimental proteoglycanbased dressing materials is described, together with an overview of the bioactive role of sulphated macromolecules. This leads to an assessment of the analogies between the sulphonate group and the sulphate group and an explanation of their unique water binding behaviour. The available information suggests the desirability of an integrated physicochemical, biochemical and biological approach to the design and synthesis of new wound healing biomaterials.
Original languageEnglish
Title of host publicationAdvanced wound repair therapies
EditorsDavid Farrar
Place of PublicationCambridge (UK)
PublisherWoodhead
Pages321-357
Number of pages37
ISBN (Print)978-1-84569-700-6
Publication statusPublished - 21 Jun 2011

Keywords

  • biomimesis
  • sulphate
  • sulphonate
  • hydrogel
  • proteoglycan
  • interfacial tension.

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  • Research Output

    Wound healing studies and interfacial phenomena: use and relevance of the corneal model

    Mann, A. M. & Tighe, B. J., 21 Jun 2011, Advanced wound repair therapies. Farrar, D. (ed.). Cambridge (UK): Woodhead, p. 284-320 37 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter

  • Cite this

    Tighe, B. J., & Mann, A. M. (2011). Sulphonated biomaterials as glycosaminoglycan mimics in wound healing. In D. Farrar (Ed.), Advanced wound repair therapies (pp. 321-357). Woodhead.