Summary of the ISEV workshop on extracellular vesicles as disease biomarkers, held in Birmingham, UK, during December 2017

Aled Clayton, Dominik Buschmann, J. Brian Byrd, David R. F. Carter, Lesley Cheng, Carolyn Compton, George Daaboul, Andrew Devitt, Juan Manuel Falcon-Perez, Chris Gardiner, Dakota Gustafson, Paul Harrison, Clemens Helmbrecht, An Hendrix, Andrew Hill, Andrew Hoffman, Jennifer C. Jones, Raghu Kalluri, Ji Yoon Kang, Benedikt Kirchner & 17 others Cecilia Lässer, Charlotte Lawson, Metka Lenassi, Carina Levin, Alicia Llorente, Elena S. Martens-Uzunova, Andreas Möller, Luca Musante, Takahiro Ochiya, Ryan C. Pink, Hidetoshi Tahara, Marca H. M. Wauben, Jason P. Webber, Joshua A. Welsh, Kenneth W. Witwer, Hang Yin, Rienk Nieuwland

Research output: Contribution to journalArticle

Abstract

This report summarises the presentations and activities of the ISEV Workshop on extracellular vesicle biomarkers held in Birmingham, UK during December 2017. Among the key messages was broad agreement about the importance of biospecimen science. Much greater attention needs to be paid towards the provenance of collected samples. The workshop also highlighted clear gaps in our knowledge about pre-analytical factors that alter extracellular vesicles (EVs). The future utility of certified standards for credentialing of instruments and software, to analyse EV and for tracking the influence of isolation steps on the structure and content of EVs were also discussed. Several example studies were presented, demonstrating the potential utility for EVs in disease diagnosis, prognosis, longitudinal serial testing and stratification of patients. The conclusion of the workshop was that more effort focused on pre-analytical issues and benchmarking of isolation methods is needed to strengthen collaborations and advance more effective biomarkers.
LanguageEnglish
Article number1473707
JournalJournal of Extracellular Vesicles
Volume7
Issue number1
DOIs
Publication statusPublished - 17 May 2018

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Biomarkers
Education
Credentialing
Benchmarking
Software
Extracellular Vesicles

Bibliographical note

© 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group on behalf of The International Society for Extracellular Vesicles.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted
use, distribution, and reproduction in any medium, provided the original work is properly cited.

Keywords

  • Biomarkers
  • extracellular vesicles
  • exomes
  • cancer
  • serum
  • plasma
  • urine

Cite this

Clayton, A., Buschmann, D., Byrd, J. B., Carter, D. R. F., Cheng, L., Compton, C., ... Nieuwland, R. (2018). Summary of the ISEV workshop on extracellular vesicles as disease biomarkers, held in Birmingham, UK, during December 2017. 7(1), [1473707]. https://doi.org/10.1080/20013078.2018.1473707
Clayton, Aled ; Buschmann, Dominik ; Byrd, J. Brian ; Carter, David R. F. ; Cheng, Lesley ; Compton, Carolyn ; Daaboul, George ; Devitt, Andrew ; Falcon-Perez, Juan Manuel ; Gardiner, Chris ; Gustafson, Dakota ; Harrison, Paul ; Helmbrecht, Clemens ; Hendrix, An ; Hill, Andrew ; Hoffman, Andrew ; Jones, Jennifer C. ; Kalluri, Raghu ; Kang, Ji Yoon ; Kirchner, Benedikt ; Lässer, Cecilia ; Lawson, Charlotte ; Lenassi, Metka ; Levin, Carina ; Llorente, Alicia ; Martens-Uzunova, Elena S. ; Möller, Andreas ; Musante, Luca ; Ochiya, Takahiro ; Pink, Ryan C. ; Tahara, Hidetoshi ; Wauben, Marca H. M. ; Webber, Jason P. ; Welsh, Joshua A. ; Witwer, Kenneth W. ; Yin, Hang ; Nieuwland, Rienk. / Summary of the ISEV workshop on extracellular vesicles as disease biomarkers, held in Birmingham, UK, during December 2017. 2018 ; Vol. 7, No. 1.
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abstract = "This report summarises the presentations and activities of the ISEV Workshop on extracellular vesicle biomarkers held in Birmingham, UK during December 2017. Among the key messages was broad agreement about the importance of biospecimen science. Much greater attention needs to be paid towards the provenance of collected samples. The workshop also highlighted clear gaps in our knowledge about pre-analytical factors that alter extracellular vesicles (EVs). The future utility of certified standards for credentialing of instruments and software, to analyse EV and for tracking the influence of isolation steps on the structure and content of EVs were also discussed. Several example studies were presented, demonstrating the potential utility for EVs in disease diagnosis, prognosis, longitudinal serial testing and stratification of patients. The conclusion of the workshop was that more effort focused on pre-analytical issues and benchmarking of isolation methods is needed to strengthen collaborations and advance more effective biomarkers.",
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Clayton, A, Buschmann, D, Byrd, JB, Carter, DRF, Cheng, L, Compton, C, Daaboul, G, Devitt, A, Falcon-Perez, JM, Gardiner, C, Gustafson, D, Harrison, P, Helmbrecht, C, Hendrix, A, Hill, A, Hoffman, A, Jones, JC, Kalluri, R, Kang, JY, Kirchner, B, Lässer, C, Lawson, C, Lenassi, M, Levin, C, Llorente, A, Martens-Uzunova, ES, Möller, A, Musante, L, Ochiya, T, Pink, RC, Tahara, H, Wauben, MHM, Webber, JP, Welsh, JA, Witwer, KW, Yin, H & Nieuwland, R 2018, 'Summary of the ISEV workshop on extracellular vesicles as disease biomarkers, held in Birmingham, UK, during December 2017' vol. 7, no. 1, 1473707. https://doi.org/10.1080/20013078.2018.1473707

Summary of the ISEV workshop on extracellular vesicles as disease biomarkers, held in Birmingham, UK, during December 2017. / Clayton, Aled; Buschmann, Dominik; Byrd, J. Brian; Carter, David R. F. ; Cheng, Lesley; Compton, Carolyn; Daaboul, George; Devitt, Andrew; Falcon-Perez, Juan Manuel; Gardiner, Chris; Gustafson, Dakota; Harrison, Paul; Helmbrecht, Clemens; Hendrix, An; Hill, Andrew; Hoffman, Andrew; Jones, Jennifer C. ; Kalluri, Raghu ; Kang, Ji Yoon; Kirchner, Benedikt; Lässer, Cecilia; Lawson, Charlotte; Lenassi, Metka; Levin, Carina; Llorente, Alicia; Martens-Uzunova, Elena S. ; Möller, Andreas; Musante, Luca; Ochiya, Takahiro; Pink, Ryan C.; Tahara, Hidetoshi; Wauben, Marca H. M. ; Webber, Jason P.; Welsh, Joshua A.; Witwer, Kenneth W.; Yin, Hang; Nieuwland, Rienk.

Vol. 7, No. 1, 1473707, 17.05.2018.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Summary of the ISEV workshop on extracellular vesicles as disease biomarkers, held in Birmingham, UK, during December 2017

AU - Clayton, Aled

AU - Buschmann, Dominik

AU - Byrd, J. Brian

AU - Carter, David R. F.

AU - Cheng, Lesley

AU - Compton, Carolyn

AU - Daaboul, George

AU - Devitt, Andrew

AU - Falcon-Perez, Juan Manuel

AU - Gardiner, Chris

AU - Gustafson, Dakota

AU - Harrison, Paul

AU - Helmbrecht, Clemens

AU - Hendrix, An

AU - Hill, Andrew

AU - Hoffman, Andrew

AU - Jones, Jennifer C.

AU - Kalluri, Raghu

AU - Kang, Ji Yoon

AU - Kirchner, Benedikt

AU - Lässer, Cecilia

AU - Lawson, Charlotte

AU - Lenassi, Metka

AU - Levin, Carina

AU - Llorente, Alicia

AU - Martens-Uzunova, Elena S.

AU - Möller, Andreas

AU - Musante, Luca

AU - Ochiya, Takahiro

AU - Pink, Ryan C.

AU - Tahara, Hidetoshi

AU - Wauben, Marca H. M.

AU - Webber, Jason P.

AU - Welsh, Joshua A.

AU - Witwer, Kenneth W.

AU - Yin, Hang

AU - Nieuwland, Rienk

N1 - © 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group on behalf of The International Society for Extracellular Vesicles. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PY - 2018/5/17

Y1 - 2018/5/17

N2 - This report summarises the presentations and activities of the ISEV Workshop on extracellular vesicle biomarkers held in Birmingham, UK during December 2017. Among the key messages was broad agreement about the importance of biospecimen science. Much greater attention needs to be paid towards the provenance of collected samples. The workshop also highlighted clear gaps in our knowledge about pre-analytical factors that alter extracellular vesicles (EVs). The future utility of certified standards for credentialing of instruments and software, to analyse EV and for tracking the influence of isolation steps on the structure and content of EVs were also discussed. Several example studies were presented, demonstrating the potential utility for EVs in disease diagnosis, prognosis, longitudinal serial testing and stratification of patients. The conclusion of the workshop was that more effort focused on pre-analytical issues and benchmarking of isolation methods is needed to strengthen collaborations and advance more effective biomarkers.

AB - This report summarises the presentations and activities of the ISEV Workshop on extracellular vesicle biomarkers held in Birmingham, UK during December 2017. Among the key messages was broad agreement about the importance of biospecimen science. Much greater attention needs to be paid towards the provenance of collected samples. The workshop also highlighted clear gaps in our knowledge about pre-analytical factors that alter extracellular vesicles (EVs). The future utility of certified standards for credentialing of instruments and software, to analyse EV and for tracking the influence of isolation steps on the structure and content of EVs were also discussed. Several example studies were presented, demonstrating the potential utility for EVs in disease diagnosis, prognosis, longitudinal serial testing and stratification of patients. The conclusion of the workshop was that more effort focused on pre-analytical issues and benchmarking of isolation methods is needed to strengthen collaborations and advance more effective biomarkers.

KW - Biomarkers

KW - extracellular vesicles

KW - exomes

KW - cancer

KW - serum

KW - plasma

KW - urine

UR - https://www.tandfonline.com/doi/full/10.1080/20013078.2018.1473707

U2 - 10.1080/20013078.2018.1473707

DO - 10.1080/20013078.2018.1473707

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