Summary of the ISEV workshop on extracellular vesicles as disease biomarkers, held in Birmingham, UK, during December 2017

Aled Clayton; Dominik Buschmann; J. Brian Byrd; David R. F.  Carter; Lesley Cheng; Carolyn Compton; George Daaboul; Andrew Devitt; Juan Manuel Falcon-Perez; Chris Gardiner; Dakota Gustafson; Paul Harrison; Clemens Helmbrecht; An Hendrix; Andrew Hill; Andrew Hoffman; Jennifer C.  Jones; Raghu  Kalluri; Ji Yoon Kang; Benedikt Kirchner; Cecilia Lässer; Charlotte Lawson; Metka Lenassi; Carina Levin; Alicia Llorente; Elena S.  Martens-Uzunova; Andreas Möller; Luca Musante; Takahiro Ochiya; Ryan C. Pink; Hidetoshi Tahara; Marca H. M.  Wauben; Jason P. Webber; Joshua A. Welsh; Kenneth W. Witwer; Hang Yin; Rienk Nieuwland

doi:10.1080/20013078.2018.1473707

Summary of the ISEV workshop on extracellular vesicles as disease biomarkers, held in Birmingham, UK, during December 2017

Aled Clayton
, Dominik Buschmann
, J. Brian Byrd
, David R. F. Carter
, Lesley Cheng
, Carolyn Compton
, George Daaboul
, Andrew Devitt
, Juan Manuel Falcon-Perez
, Chris Gardiner
, Dakota Gustafson
, Paul Harrison
, Clemens Helmbrecht
, An Hendrix
, Andrew Hill
, Andrew Hoffman
, Jennifer C. Jones
, Raghu Kalluri
, Ji Yoon Kang
, Benedikt Kirchner

Cecilia Lässer, Charlotte Lawson, Metka Lenassi, Carina Levin, Alicia Llorente, Elena S. Martens-Uzunova, Andreas Möller, Luca Musante, Takahiro Ochiya, Ryan C. Pink, Hidetoshi Tahara, Marca H. M. Wauben, Jason P. Webber, Joshua A. Welsh, Kenneth W. Witwer, Hang Yin, Rienk Nieuwland

Technische Universität München
University of Michigan
Oxford Brookes University
La Trobe University
Arizona State University
nanoView Diagnostics
IKERBASQUE Research Foundation
University College London
University of Toronto
University College Birmingham
Particle Metrix GmbH
Universiteit Gent
UT MD Anderson Cancer Center
Korea Institute of Science and Technology
Göteborgs Universitet
Royal Veterinary College University of London
Univerza v Ljubljani
Emek Medical Center
Oslo University Hospital Rikshospitalet
Erasmus MC
QIMR Berghofer Medical Research Institute
University of Virginia
National Cancer Center Research Institute
Hiroshima University
Universiteit Utrecht
Cardiff University
National Cancer Institute
Johns Hopkins University
Tsinghua University
Universiteit van Amsterdam
Tufts University

Research output: Contribution to journal › Article › peer-review

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Abstract

This report summarises the presentations and activities of the ISEV Workshop on extracellular vesicle biomarkers held in Birmingham, UK during December 2017. Among the key messages was broad agreement about the importance of biospecimen science. Much greater attention needs to be paid towards the provenance of collected samples. The workshop also highlighted clear gaps in our knowledge about pre-analytical factors that alter extracellular vesicles (EVs). The future utility of certified standards for credentialing of instruments and software, to analyse EV and for tracking the influence of isolation steps on the structure and content of EVs were also discussed. Several example studies were presented, demonstrating the potential utility for EVs in disease diagnosis, prognosis, longitudinal serial testing and stratification of patients. The conclusion of the workshop was that more effort focused on pre-analytical issues and benchmarking of isolation methods is needed to strengthen collaborations and advance more effective biomarkers.

Original language	English
Article number	1473707
Journal	Journal of Extracellular Vesicles
Volume	7
Issue number	1
DOIs	https://doi.org/10.1080/20013078.2018.1473707
Publication status	Published - 17 May 2018

Bibliographical note

© 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group on behalf of The International Society for Extracellular Vesicles.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted
use, distribution, and reproduction in any medium, provided the original work is properly cited.

Keywords

Biomarkers
extracellular vesicles
exomes
cancer
serum
plasma
urine

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10.1080/20013078.2018.1473707Licence: CC BY 3.0

Summary of the ISEV workshop on extracellular vesicles as disease biomarkers held in Birmingham UK during December 2017
© 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group on behalf of The International Society for Extracellular Vesicles. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Final published version, 2.33 MBLicence: CC BY 3.0

Cite this

Clayton, A., Buschmann, D., Byrd, J. B., Carter, D. R. F., Cheng, L., Compton, C., Daaboul, G., Devitt, A., Falcon-Perez, J. M., Gardiner, C., Gustafson, D., Harrison, P., Helmbrecht, C., Hendrix, A., Hill, A., Hoffman, A., Jones, J. C., Kalluri, R., Kang, J. Y., ... Nieuwland, R. (2018). Summary of the ISEV workshop on extracellular vesicles as disease biomarkers, held in Birmingham, UK, during December 2017. Journal of Extracellular Vesicles , 7(1), Article 1473707. https://doi.org/10.1080/20013078.2018.1473707

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abstract = "This report summarises the presentations and activities of the ISEV Workshop on extracellular vesicle biomarkers held in Birmingham, UK during December 2017. Among the key messages was broad agreement about the importance of biospecimen science. Much greater attention needs to be paid towards the provenance of collected samples. The workshop also highlighted clear gaps in our knowledge about pre-analytical factors that alter extracellular vesicles (EVs). The future utility of certified standards for credentialing of instruments and software, to analyse EV and for tracking the influence of isolation steps on the structure and content of EVs were also discussed. Several example studies were presented, demonstrating the potential utility for EVs in disease diagnosis, prognosis, longitudinal serial testing and stratification of patients. The conclusion of the workshop was that more effort focused on pre-analytical issues and benchmarking of isolation methods is needed to strengthen collaborations and advance more effective biomarkers.",

keywords = "Biomarkers, extracellular vesicles, exomes, cancer, serum, plasma, urine",

author = "Aled Clayton and Dominik Buschmann and Byrd, \{J. Brian\} and Carter, \{David R. F.\} and Lesley Cheng and Carolyn Compton and George Daaboul and Andrew Devitt and Falcon-Perez, \{Juan Manuel\} and Chris Gardiner and Dakota Gustafson and Paul Harrison and Clemens Helmbrecht and An Hendrix and Andrew Hill and Andrew Hoffman and Jones, \{Jennifer C.\} and Raghu Kalluri and Kang, \{Ji Yoon\} and Benedikt Kirchner and Cecilia L{\"a}sser and Charlotte Lawson and Metka Lenassi and Carina Levin and Alicia Llorente and Martens-Uzunova, \{Elena S.\} and Andreas M{\"o}ller and Luca Musante and Takahiro Ochiya and Pink, \{Ryan C.\} and Hidetoshi Tahara and Wauben, \{Marca H. M.\} and Webber, \{Jason P.\} and Welsh, \{Joshua A.\} and Witwer, \{Kenneth W.\} and Hang Yin and Rienk Nieuwland",

note = "{\textcopyright} 2018 The Author(s). Published by Informa UK Limited, trading as Taylor \& Francis Group on behalf of The International Society for Extracellular Vesicles. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.",

year = "2018",

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doi = "10.1080/20013078.2018.1473707",

language = "English",

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Clayton, A, Buschmann, D, Byrd, JB, Carter, DRF, Cheng, L, Compton, C, Daaboul, G, Devitt, A, Falcon-Perez, JM, Gardiner, C, Gustafson, D, Harrison, P, Helmbrecht, C, Hendrix, A, Hill, A, Hoffman, A, Jones, JC, Kalluri, R, Kang, JY, Kirchner, B, Lässer, C, Lawson, C, Lenassi, M, Levin, C, Llorente, A, Martens-Uzunova, ES, Möller, A, Musante, L, Ochiya, T, Pink, RC, Tahara, H, Wauben, MHM, Webber, JP, Welsh, JA, Witwer, KW, Yin, H & Nieuwland, R 2018, 'Summary of the ISEV workshop on extracellular vesicles as disease biomarkers, held in Birmingham, UK, during December 2017', Journal of Extracellular Vesicles , vol. 7, no. 1, 1473707. https://doi.org/10.1080/20013078.2018.1473707

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AU - Clayton, Aled

AU - Buschmann, Dominik

AU - Byrd, J. Brian

AU - Carter, David R. F.

AU - Cheng, Lesley

AU - Compton, Carolyn

AU - Daaboul, George

AU - Devitt, Andrew

AU - Falcon-Perez, Juan Manuel

AU - Gardiner, Chris

AU - Gustafson, Dakota

AU - Harrison, Paul

AU - Helmbrecht, Clemens

AU - Hendrix, An

AU - Hill, Andrew

AU - Hoffman, Andrew

AU - Jones, Jennifer C.

AU - Kalluri, Raghu

AU - Kang, Ji Yoon

AU - Kirchner, Benedikt

AU - Lässer, Cecilia

AU - Lawson, Charlotte

AU - Lenassi, Metka

AU - Levin, Carina

AU - Llorente, Alicia

AU - Martens-Uzunova, Elena S.

AU - Möller, Andreas

AU - Musante, Luca

AU - Ochiya, Takahiro

AU - Pink, Ryan C.

AU - Tahara, Hidetoshi

AU - Wauben, Marca H. M.

AU - Webber, Jason P.

AU - Welsh, Joshua A.

AU - Witwer, Kenneth W.

AU - Yin, Hang

AU - Nieuwland, Rienk

N1 - © 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group on behalf of The International Society for Extracellular Vesicles. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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AB - This report summarises the presentations and activities of the ISEV Workshop on extracellular vesicle biomarkers held in Birmingham, UK during December 2017. Among the key messages was broad agreement about the importance of biospecimen science. Much greater attention needs to be paid towards the provenance of collected samples. The workshop also highlighted clear gaps in our knowledge about pre-analytical factors that alter extracellular vesicles (EVs). The future utility of certified standards for credentialing of instruments and software, to analyse EV and for tracking the influence of isolation steps on the structure and content of EVs were also discussed. Several example studies were presented, demonstrating the potential utility for EVs in disease diagnosis, prognosis, longitudinal serial testing and stratification of patients. The conclusion of the workshop was that more effort focused on pre-analytical issues and benchmarking of isolation methods is needed to strengthen collaborations and advance more effective biomarkers.

KW - Biomarkers

KW - extracellular vesicles

KW - exomes

KW - cancer

KW - serum

KW - plasma

KW - urine

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DO - 10.1080/20013078.2018.1473707

M3 - Article

SN - 2001-3078

VL - 7

JO - Journal of Extracellular Vesicles

JF - Journal of Extracellular Vesicles

IS - 1

M1 - 1473707

ER -

Summary of the ISEV workshop on extracellular vesicles as disease biomarkers, held in Birmingham, UK, during December 2017

Abstract

Bibliographical note

Keywords

Access to Document

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