Sustained delivery of salbutamol and beclometasone from spray-dried double emulsions

Tristan P. Learoyd, Jane L. Burrows, Eddie French, Peter C. Seville

Research output: Contribution to journalArticle

Abstract

The sustained delivery of multiple agents to the lung offers potential benefits to patients. This study explores the preparation of highly respirable dual-loaded spray-dried double emulsions. Spray-dried powders were produced from water-in-oil-in-water (w/o/w) double emulsions, containing salbutamol sulphate and/or beclometasone dipropionate in varying phases. The double emulsions contained the drug release modifier polylactide co-glycolide (PLGA 50 : 50) in the intermediate organic phase of the original micro-emulsion and low molecular weight chitosan (Mw<190 kDa: emulsion stabilizer) and leucine (aerosolization enhancer) in the tertiary aqueous phase. Following spray-drying resultant powders were physically characterized: with in vitro aerosolization performance and drug release investigated using a Multi-Stage Liquid Impinger and modified USP II dissolution apparatus, respectively. Powders generated were of a respirable size exhibiting emitted doses of over 95% and fine particle fractions of up to 60% of the total loaded dose. Sustained drug release profiles were observed during dissolution for powders containing agents in the primary aqueous and secondary organic phases of the original micro-emulsion; the burst release of agents was witnessed from the tertiary aqueous phase. The novel spray-dried emulsions from this study would be expected to deposit and display sustained release character in the lung.

Original languageEnglish
Pages (from-to)162-170
Number of pages9
JournalJournal of Microencapsulation
Volume27
Issue number2
Early online date11 May 2009
DOIs
Publication statusPublished - 2010

Keywords

  • chitosan
  • double emulsion
  • PLGA
  • respirable
  • spray drying

Fingerprint Dive into the research topics of 'Sustained delivery of salbutamol and beclometasone from spray-dried double emulsions'. Together they form a unique fingerprint.

  • Cite this