Polystyrene microbeads doped with highly luminescent CdS quantum dots (QDs) have been prepared. Polystyrene particles with diameters ranging from 100 nm to 500 urn were prepared by a suspension polymerization method and with different loadings of QDs. The resulting organic-inorganic microspheres have been characterized by FTIR, elemental analysis and SEM. Confocal microscopy and photoluminescence studies proved that the CdS nanoparticles were evenly distributed throughout the polystyrene spheres. The QD-containing composites have similar optical properties to isolated CdS QDs. The thermal decomposition of the hybrid materials occurred at higher temperature than for the parent organic materials.