Synthesis and evaluation of asperlicin analogues as non-peptidal cholecystokinin-antagonists

Keyphrases

• 1,4-Benzodiazepin-2-one 50%
• 1,4-Benzodiazepine 100%
• 2-aminoacetophenone 50%
• 3-step 100%
• Acylation Reaction 50%
• Alkylation Reaction 50%
• Azepine 50%
• Bioactive 50%
• C-3 Position 50%
• Cholecystokinin 100%
• Disubstituted 50%
• IC50 50%
• Indol 50%
• Indole 50%
• Methyl 50%
• Monosubstituted 50%
• Overall Yield 50%
• Reaction Sequence 50%
• Receptor Subtypes 50%
• Regioselective Alkylation 50%
• SAR Optimization 50%
• Selective Acylation 50%
• Side Chain 50%
• Substructure 50%
• Tryptophan 100%

Pharmacology, Toxicology and Pharmaceutical Science

• Acetophenone Derivative 25%
• Asperlicin 100%
• Azepine Derivative 25%
• Benzodiazepine 50%
• Cholecystokinin Receptor Blocking Agent 100%
• IC50 25%
• Indole 50%
• Receptor Subtype 25%
• Structure Activity Relationship 50%
• Tryptophan 50%

Chemistry

• 1,4-benzodiazepine 50%
• Acetophenone 25%
• Acylation 25%
• Alkylation 25%
• Asperlicin 100%
• Azepine 25%
• Cholecystokinin Receptor Blocking Agent 100%
• IC50 25%
• Indole 25%
• Reaction Step 25%
• Tryptophan 50%