Synthesis and evaluation of N-(3-oxo-2,3-dihydro-1H-pyrazol-4-yl)-1H-indole-carboxamides as cholecystokinin antagonists

Keyphrases

• Cholecystokinin 100%
• 1H-indole 100%
• Pyrazol 100%
• Indolecarboxamide 100%
• Diphenyl 66%
• Amides 66%
• Antidepressants 66%
• IC50 33%
• 125I 33%
• Structure-activity Relationship 33%
• Anxiolytic Activity 33%
• Receptor Binding Assay 33%
• ED50 33%
• High Dose 33%
• Swimming Test 33%
• Despair 33%
• CCK1 Receptor 33%
• In Vivo Evaluation 33%
• Pyrazoline 33%
• Cell Counting kit-8 (CCK-8) 33%
• Pharmacological Assays 33%
• Elevated Plus Maze 33%

Pharmacology, Toxicology and Pharmaceutical Science

• Cholecystokinin Receptor Blocking Agent 100%
• Indole 100%
• Carboxamide 100%
• Cholecystokinin 60%
• Biphenyl 40%
• Antidepressant 40%
• Iodine-125 20%
• IC50 20%
• Structure Activity Relationship 20%
• Ligand Binding Assay 20%
• Cholecystokinin A Receptor 20%
• Desipramine 20%
• Cholecystokinin Octapeptide 20%

Biochemistry, Genetics and Molecular Biology

• Cholecystokinin 100%
• IC50 20%
• Iodine-125 20%
• DNA Template 20%
• Structure Activity Relation 20%
• Cholecystokinin A Receptor 20%
• Hopelessness 20%
• Ligand Binding Assay 20%
• Antidepressant Activity 20%
• Drug Megadose 20%
• ED50 20%