Synthesis and evaluation of poly(oxyethylene glycol) polymer (POP) supports

Mark C. McCairn, Stephen R. Tonge, Andrew J Sutherland*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Mono- and α,ω-bis-styryl-oligo(oxyethylene glycol) ethers have been constructed in an efficient two-step synthesis. From these precursors, poly(oxyethylene glycol) polymer (POP) supports of varying monomer and cross-linker composition have been produced. The swelling properties and mass-solvent uptake of these novel materials have been evaluated in a variety of solvents, demonstrating that POP supports exhibit enhanced solvent compatibilities over the commercial resins TENTA-GEL, ARGO-GEL, and Merrifield's resin. The utility of POP supports in solid-phase organic chemistry has also been demonstrated successfully. It is anticipated that these high-loading polymeric supports will have generic application in the solid-phase synthesis of combinatorial libraries and the in situ screening of these libraries in the aqueous environment of a bioassay.
Original languageEnglish
Pages (from-to)4847-4855
JournalJournal of Organic Chemistry
Issue number14
Publication statusPublished - 1 Jul 2002


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