Synthesis and evaluation of poly(oxyethylene glycol) polymer (POP) supports

Mark C. McCairn; Stephen R. Tonge; Andrew J Sutherland

doi:10.1021/jo020071b

Synthesis and evaluation of poly(oxyethylene glycol) polymer (POP) supports

Mark C. McCairn, Stephen R. Tonge, Andrew J Sutherland^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Mono- and α,ω-bis-styryl-oligo(oxyethylene glycol) ethers have been constructed in an efficient two-step synthesis. From these precursors, poly(oxyethylene glycol) polymer (POP) supports of varying monomer and cross-linker composition have been produced. The swelling properties and mass-solvent uptake of these novel materials have been evaluated in a variety of solvents, demonstrating that POP supports exhibit enhanced solvent compatibilities over the commercial resins TENTA-GEL, ARGO-GEL, and Merrifield's resin. The utility of POP supports in solid-phase organic chemistry has also been demonstrated successfully. It is anticipated that these high-loading polymeric supports will have generic application in the solid-phase synthesis of combinatorial libraries and the in situ screening of these libraries in the aqueous environment of a bioassay.

Original language	English
Pages (from-to)	4847-4855
Journal	Journal of Organic Chemistry
Volume	67
Issue number	14
DOIs	https://doi.org/10.1021/jo020071b
Publication status	Published - 1 Jul 2002

Access to Document

10.1021/jo020071b

Cite this

@article{612db2070d8347acabe642dbd521ce34,

title = "Synthesis and evaluation of poly(oxyethylene glycol) polymer (POP) supports",

abstract = "Mono- and α,ω-bis-styryl-oligo(oxyethylene glycol) ethers have been constructed in an efficient two-step synthesis. From these precursors, poly(oxyethylene glycol) polymer (POP) supports of varying monomer and cross-linker composition have been produced. The swelling properties and mass-solvent uptake of these novel materials have been evaluated in a variety of solvents, demonstrating that POP supports exhibit enhanced solvent compatibilities over the commercial resins TENTA-GEL, ARGO-GEL, and Merrifield's resin. The utility of POP supports in solid-phase organic chemistry has also been demonstrated successfully. It is anticipated that these high-loading polymeric supports will have generic application in the solid-phase synthesis of combinatorial libraries and the in situ screening of these libraries in the aqueous environment of a bioassay.",

author = "McCairn, {Mark C.} and Tonge, {Stephen R.} and Sutherland, {Andrew J}",

year = "2002",

month = jul,

day = "1",

doi = "10.1021/jo020071b",

language = "English",

volume = "67",

pages = "4847--4855",

journal = "Journal of Organic Chemistry",

issn = "0022-3263",

publisher = "American Chemical Society",

number = "14",

}

TY - JOUR

T1 - Synthesis and evaluation of poly(oxyethylene glycol) polymer (POP) supports

AU - McCairn, Mark C.

AU - Tonge, Stephen R.

AU - Sutherland, Andrew J

PY - 2002/7/1

Y1 - 2002/7/1

N2 - Mono- and α,ω-bis-styryl-oligo(oxyethylene glycol) ethers have been constructed in an efficient two-step synthesis. From these precursors, poly(oxyethylene glycol) polymer (POP) supports of varying monomer and cross-linker composition have been produced. The swelling properties and mass-solvent uptake of these novel materials have been evaluated in a variety of solvents, demonstrating that POP supports exhibit enhanced solvent compatibilities over the commercial resins TENTA-GEL, ARGO-GEL, and Merrifield's resin. The utility of POP supports in solid-phase organic chemistry has also been demonstrated successfully. It is anticipated that these high-loading polymeric supports will have generic application in the solid-phase synthesis of combinatorial libraries and the in situ screening of these libraries in the aqueous environment of a bioassay.

AB - Mono- and α,ω-bis-styryl-oligo(oxyethylene glycol) ethers have been constructed in an efficient two-step synthesis. From these precursors, poly(oxyethylene glycol) polymer (POP) supports of varying monomer and cross-linker composition have been produced. The swelling properties and mass-solvent uptake of these novel materials have been evaluated in a variety of solvents, demonstrating that POP supports exhibit enhanced solvent compatibilities over the commercial resins TENTA-GEL, ARGO-GEL, and Merrifield's resin. The utility of POP supports in solid-phase organic chemistry has also been demonstrated successfully. It is anticipated that these high-loading polymeric supports will have generic application in the solid-phase synthesis of combinatorial libraries and the in situ screening of these libraries in the aqueous environment of a bioassay.

UR - https://pubs.acs.org/doi/10.1021/jo020071b

U2 - 10.1021/jo020071b

DO - 10.1021/jo020071b

M3 - Article

SN - 0022-3263

VL - 67

SP - 4847

EP - 4855

JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

IS - 14

ER -

Synthesis and evaluation of poly(oxyethylene glycol) polymer (POP) supports

Abstract

Access to Document

Other files and links

Fingerprint

Cite this