TY - JOUR
T1 - Synthesis and stability of oligonucleotide duplexes containing N4 aralkyl-substituted cytosine bases
AU - Wallis, Mark P.
AU - Schwalbe, Carl H.
AU - Fraser, William
N1 - Copyright 2004 Elsevier Science B.V., Amsterdam. All rights reserved.
PY - 1997/1/1
Y1 - 1997/1/1
N2 - N4 aralkyl-substituted cytosine nucleosides, available directly by displacement of the PfpO group at C4 of 5'-O-DMT-protected nucleoside 4, were efficiently incorporated into short oligonucleotides. Aralkyl substitution at the N4 of cytosine was entropically stabilising but offset by loss in enthalpy resulting overall in duplex destabilisation.
AB - N4 aralkyl-substituted cytosine nucleosides, available directly by displacement of the PfpO group at C4 of 5'-O-DMT-protected nucleoside 4, were efficiently incorporated into short oligonucleotides. Aralkyl substitution at the N4 of cytosine was entropically stabilising but offset by loss in enthalpy resulting overall in duplex destabilisation.
UR - http://www.scopus.com/inward/record.url?scp=0031469118&partnerID=8YFLogxK
UR - http://www.tandfonline.com/doi/pdf/10.1080/07328319708002555
U2 - 10.1080/07328319708002555
DO - 10.1080/07328319708002555
M3 - Article
AN - SCOPUS:0031469118
SN - 0732-8311
VL - 16
SP - 2053
EP - 2068
JO - Nucleosides, Nucleotides and Nucleic Acids
JF - Nucleosides, Nucleotides and Nucleic Acids
IS - 10-11
ER -