Synthesis and stability of oligonucleotide duplexes containing N4 aralkyl-substituted cytosine bases

Mark P. Wallis, Carl H. Schwalbe, William Fraser

Research output: Contribution to journalArticlepeer-review

Abstract

N4 aralkyl-substituted cytosine nucleosides, available directly by displacement of the PfpO group at C4 of 5'-O-DMT-protected nucleoside 4, were efficiently incorporated into short oligonucleotides. Aralkyl substitution at the N4 of cytosine was entropically stabilising but offset by loss in enthalpy resulting overall in duplex destabilisation.
Original languageEnglish
Pages (from-to)2053-2068
Number of pages16
JournalNucleosides, Nucleotides and Nucleic Acids
Volume16
Issue number10-11
DOIs
Publication statusPublished - 1 Jan 1997

Bibliographical note

Copyright 2004 Elsevier Science B.V., Amsterdam. All rights reserved.

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