Synthesis of elastic biodegradable polyesters of ethylene glycol and butylene glycol from sebacic acid

Hyung-seok Park, Jung-a Seo, Hye-Young Lee, Hae-Won Kim, Ivan B Wall, Myoung-Seon Gong, Jonathan C Knowles

Research output: Contribution to journalArticlepeer-review

Abstract

High molecular weight biodegradable polyesters were prepared from sebacic acid, ethylene glycol and butylene glycol through a simple non-solvent polycondensation with a low toxicity catalyst. The successful synthesis of the polyesters was confirmed by gel permeation chromatography, (1)H-nuclear magnetic resonance and Fourier transform-infrared spectroscopies and differential scanning calorimetry. The degradation tests were performed at 37 °C in phosphate buffer solution (pH 7.4) and showed a mass loss of ~5% over 12 weeks compared with only 2% for polycaprolactone (PCL). Reverse transcription polymerase chain reaction results following culture of osteoblasts on the polymer surface showed that poly(ethylene sebacate) and poly(butylene sebacate) films were optimal for osteoblast formation in terms of Runx 2 and osteocalcin gene expression.

Original languageEnglish
Pages (from-to)2911-2918
Number of pages8
JournalActa Biomaterialia
Volume8
Issue number8
DOIs
Publication statusPublished - Aug 2012

Bibliographical note

Copyright © 2012 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

Keywords

  • Animals
  • Biocompatible Materials/chemical synthesis
  • Biodegradation, Environmental/drug effects
  • Biomarkers/metabolism
  • Bone Marrow Cells/cytology
  • Butylene Glycols/chemistry
  • Decanoic Acids/chemistry
  • Dicarboxylic Acids/chemistry
  • Elastic Modulus/drug effects
  • Elasticity/drug effects
  • Ethylene Glycol/chemistry
  • Gene Expression Regulation/drug effects
  • Magnetic Resonance Spectroscopy
  • Materials Testing
  • Mice
  • Microscopy, Electron, Scanning
  • Molecular Weight
  • Osteogenesis/drug effects
  • Polyesters/chemical synthesis
  • Rats
  • Spectroscopy, Fourier Transform Infrared
  • Stromal Cells/cytology
  • Surface Properties/drug effects
  • Temperature
  • Tensile Strength/drug effects

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