Synthesis, self-assembly and (absence of) protein interactions of poly(glycerol methacrylate)-silicone macro-amphiphiles

Ghislaine Robert-Nicoud, Robert Evans, Cong-Duan Vo, Christopher J. Cadman, Nicola Tirelli

Research output: Contribution to journalArticle

Abstract

The present study focuses on the synthesis of amphiphilic block copolymers containing poly(glycerol monomethacrylate) (PGMMA), showing the advantages of a protection/deprotection strategy based on silyl groups. PGMMA blocks were synthesized via ATRP started by a double functional poly(dimethyl siloxane) (PDMS) macroinitiator of molecular weight ≈7000 g mol-1. The resulting triblock copolymers were characterized by low polydispersity (generally ≤1.1) and their aggregation concentration in water was essentially dominated by the PDMS block length (critical aggregation concentration substantially invariant for GMMA degree of polymerization ≥30). For GMMA blocks with DP > 50, the self-assembly in water produced 35-50 nm spherical micelles, while shorter hydrophilic chains produced larger aggregates apparently displaying worm-like morphologies. Block copolymers with long GMMA chains (DP ≈ 200) produced particularly stable micellar aggregates, which were then selected for a preliminary assessment of the possibility of adsorption of plasma proteins (albumin and fibrinogen); using diffusion NMR as an analytical technique, no significant adsorption was recorded both on micelles and on soluble PGMMA employed as a control, indicating the possibility of a "stealth" behaviour. This journal is

LanguageEnglish
Pages3458-3470
Number of pages13
JournalPolymer Chemistry
Volume4
Issue number12
Early online date3 Apr 2013
DOIs
Publication statusPublished - 21 Jun 2013

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Amphiphiles
Methacrylates
Silicones
Glycerol
Self assembly
Siloxanes
Block copolymers
Macros
Micelles
Proteins
Adsorption
Agglomeration
Water
Atom transfer radical polymerization
Polydispersity
Serum Albumin
Polymerization
Fibrinogen
Blood Proteins
Albumins

Cite this

Robert-Nicoud, Ghislaine ; Evans, Robert ; Vo, Cong-Duan ; Cadman, Christopher J. ; Tirelli, Nicola. / Synthesis, self-assembly and (absence of) protein interactions of poly(glycerol methacrylate)-silicone macro-amphiphiles. In: Polymer Chemistry. 2013 ; Vol. 4, No. 12. pp. 3458-3470.
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Synthesis, self-assembly and (absence of) protein interactions of poly(glycerol methacrylate)-silicone macro-amphiphiles. / Robert-Nicoud, Ghislaine; Evans, Robert; Vo, Cong-Duan; Cadman, Christopher J.; Tirelli, Nicola.

In: Polymer Chemistry, Vol. 4, No. 12, 21.06.2013, p. 3458-3470.

Research output: Contribution to journalArticle

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