A big challenge for European train companies in the next year will be upgrading large parts of interlocking and signaling to enable Europe-wide train transport. Additional transitions having heavy impact on infrastructure development, including the transition from conventional to high-speed trains and the application of new operation patterns in rail freight aimed at increasing the share of rail in the freight market. The main aspect in accomplishing this transformation is the development and deployment of new technology, but focusing only on technology will fail, since many other organizational components are involved in this transformation. This chapter proposes a holistic approach, starting with gathering customers’ requirements, while also respecting development of the organization as a whole and the personal development of employees. This chapter extends various earlier works of the authors and shows how extending the principles of systems engineering to other domains can help to manage this transformation successfully. The conclusion presents a reference process for service development that can be used as a blue print for participating companies.