Tailoring treatment to the individual in type 2 diabetes practical guidance from the Global Partnership for Effective Diabetes Management

Stefano Del Prato, J. LaSalle, S. Matthaei, Clifford Bailey,

Research output: Contribution to journalArticlepeer-review


Good glycaemic control continues to be the most effective therapeutic manoeuvre to reduce the risk of development and/or progression of microvascular disease, and therefore remains the cornerstone of diabetes management despite recent scepticism about tight glucose control strategies. The impact on macrovascular complications is still a matter of debate, and so glycaemic control strategies should be placed in the context of multifactorial intervention to address all cardiovascular risk factors. Approaches to achieve glycaemic targets should always ensure patient safety, and results from recent landmark outcome studies support the need for appropriate individualisation of glycaemic targets and of the means to achieve these targets, with the ultimate aim to optimise outcomes and minimise adverse events, such as hypoglycaemia and marked weight gain. The primary goal of the Global Partnership for Effective Diabetes Management is the provision of practical guidance to improve patient outcomes and, in this article, we aim to support healthcare professionals in appropriately tailoring type 2 diabetes treatment to the individual. Patient groups requiring special consideration are identified, including newly diagnosed individuals with type 2 diabetes but no complications, individuals with a history of inadequate glycaemic control, those with a history of cardiovascular disease, children and individuals at risk of hypoglycaemia. Practical guidance specific to each group is provided.
Original languageEnglish
Pages (from-to)295-304
Number of pages10
JournalInternational Journal of Clinical Practice
Issue number3
Early online date11 Jan 2010
Publication statusPublished - Feb 2010

Bibliographical note

© 2010 Blackwell Publishing Ltd
Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation.


  • adult
  • blood glucose
  • child
  • type 2 diabetes mellitus
  • diabetic angiopathies
  • humans
  • hypoglycemia
  • hypoglycemic agents
  • obesity
  • overweight
  • practice guidelines as topic
  • thinness


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