Technology in Parkinson's disease: challenges and opportunities

Alberto J. Espay; Paolo Bonato; Fatta B. Nahab; Walter Maetzler; John M. Dean; Jochen Klucken; Bjoern M. Eskofier; Aristide Merola; Fay Horak; Anthony E. Lang; Ralf Reilmann; Joe Giuffrida; Alice Nieuwboer; Malcolm Horne; Max A. Little; Irene Litvan; Tanya Simuni; E. Ray Dorsey; Michelle A. Burack; Ken Kubota; Anita Kamondi; Catarina Godinho; Jean-Francois Daneault; Georgia Mitsi; Lothar Krinke; Jeffery M. Hausdorff; Bastiaan R. Bloem; Spyros Papapetropoulos

doi:10.1002/mds.26642

Technology in Parkinson's disease: challenges and opportunities

Alberto J. Espay^*, Paolo Bonato, Fatta B. Nahab, Walter Maetzler, John M. Dean, Jochen Klucken, Bjoern M. Eskofier, Aristide Merola, Fay Horak, Anthony E. Lang, Ralf Reilmann, Joe Giuffrida, Alice Nieuwboer, Malcolm Horne, Max A. Little, Irene Litvan, Tanya Simuni, E. Ray Dorsey, Michelle A. Burack, Ken KubotaAnita Kamondi, Catarina Godinho, Jean-Francois Daneault, Georgia Mitsi, Lothar Krinke, Jeffery M. Hausdorff, Bastiaan R. Bloem, Spyros Papapetropoulos,

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

The miniaturization, sophistication, proliferation, and accessibility of technologies are enabling the capture of more and previously inaccessible phenomena in Parkinson's disease (PD). However, more information has not translated into a greater understanding of disease complexity to satisfy diagnostic and therapeutic needs. Challenges include noncompatible technology platforms, the need for wide-scale and long-term deployment of sensor technology (among vulnerable elderly patients in particular), and the gap between the "big data" acquired with sensitive measurement technologies and their limited clinical application. Major opportunities could be realized if new technologies are developed as part of open-source and/or open-hardware platforms that enable multichannel data capture sensitive to the broad range of motor and nonmotor problems that characterize PD and are adaptable into self-adjusting, individualized treatment delivery systems. The International Parkinson and Movement Disorders Society Task Force on Technology is entrusted to convene engineers, clinicians, researchers, and patients to promote the development of integrated measurement and closed-loop therapeutic systems with high patient adherence that also serve to (1) encourage the adoption of clinico-pathophysiologic phenotyping and early detection of critical disease milestones, (2) enhance the tailoring of symptomatic therapy, (3) improve subgroup targeting of patients for future testing of disease-modifying treatments, and (4) identify objective biomarkers to improve the longitudinal tracking of impairments in clinical care and research. This article summarizes the work carried out by the task force toward identifying challenges and opportunities in the development of technologies with potential for improving the clinical management and the quality of life of individuals with PD. © 2016 International Parkinson and Movement Disorder Society.

Original language	English
Pages (from-to)	1272-1282
Number of pages	11
Journal	Movement Disorders
Volume	31
Issue number	9
Early online date	29 Apr 2016
DOIs	https://doi.org/10.1002/mds.26642
Publication status	Published - Sept 2016

Bibliographical note

This is the peer reviewed version of the following article: EEspay, A. J., Bonato, P., Nahab, F. B., Maetzler, W., Dean, J. M., Klucken, J., ... Movement Disorders Society Task Force on Technology (2016). Technology in Parkinson's disease: challenges and opportunities. Movement Disorders, 31(9), 1272-1282, which has been published in final form at http://dx.doi.org/10.1002/mds.26642. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.

Keywords

digital biomarkers
digital health
eHealth
Parkinson's disease
precision medicine
remote monitoring
technology
wearable technology

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10.1002/mds.26642

Technology in Parkinson's disease_challenges and opportunities
This is the peer reviewed version of the following article: EEspay, A. J., Bonato, P., Nahab, F. B., Maetzler, W., Dean, J. M., Klucken, J., ... Movement Disorders Society Task Force on Technology (2016). Technology in Parkinson's disease: challenges and opportunities. Movement Disorders, 31(9), 1272-1282, which has been published in final form at http://dx.doi.org/10.1002/mds.26642. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Accepted author manuscript, 557 KBLicence: Unspecified

http://onlinelibrary.wiley.com/doi/10.1002/mds.26642/abstract

Cite this

Espay, A. J., Bonato, P., Nahab, F. B., Maetzler, W., Dean, J. M., Klucken, J., Eskofier, B. M., Merola, A., Horak, F., Lang, A. E., Reilmann, R., Giuffrida, J., Nieuwboer, A., Horne, M., Little, M. A., Litvan, I., Simuni, T., Dorsey, E. R., Burack, M. A. (2016). Technology in Parkinson's disease: challenges and opportunities. Movement Disorders, 31(9), 1272-1282. https://doi.org/10.1002/mds.26642

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title = "Technology in Parkinson's disease: challenges and opportunities",

abstract = "The miniaturization, sophistication, proliferation, and accessibility of technologies are enabling the capture of more and previously inaccessible phenomena in Parkinson's disease (PD). However, more information has not translated into a greater understanding of disease complexity to satisfy diagnostic and therapeutic needs. Challenges include noncompatible technology platforms, the need for wide-scale and long-term deployment of sensor technology (among vulnerable elderly patients in particular), and the gap between the {"}big data{"} acquired with sensitive measurement technologies and their limited clinical application. Major opportunities could be realized if new technologies are developed as part of open-source and/or open-hardware platforms that enable multichannel data capture sensitive to the broad range of motor and nonmotor problems that characterize PD and are adaptable into self-adjusting, individualized treatment delivery systems. The International Parkinson and Movement Disorders Society Task Force on Technology is entrusted to convene engineers, clinicians, researchers, and patients to promote the development of integrated measurement and closed-loop therapeutic systems with high patient adherence that also serve to (1) encourage the adoption of clinico-pathophysiologic phenotyping and early detection of critical disease milestones, (2) enhance the tailoring of symptomatic therapy, (3) improve subgroup targeting of patients for future testing of disease-modifying treatments, and (4) identify objective biomarkers to improve the longitudinal tracking of impairments in clinical care and research. This article summarizes the work carried out by the task force toward identifying challenges and opportunities in the development of technologies with potential for improving the clinical management and the quality of life of individuals with PD. {\textcopyright} 2016 International Parkinson and Movement Disorder Society.",

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author = "Espay, {Alberto J.} and Paolo Bonato and Nahab, {Fatta B.} and Walter Maetzler and Dean, {John M.} and Jochen Klucken and Eskofier, {Bjoern M.} and Aristide Merola and Fay Horak and Lang, {Anthony E.} and Ralf Reilmann and Joe Giuffrida and Alice Nieuwboer and Malcolm Horne and Little, {Max A.} and Irene Litvan and Tanya Simuni and Dorsey, {E. Ray} and Burack, {Michelle A.} and Ken Kubota and Anita Kamondi and Catarina Godinho and Jean-Francois Daneault and Georgia Mitsi and Lothar Krinke and Hausdorff, {Jeffery M.} and Bloem, {Bastiaan R.} and Spyros Papapetropoulos",

note = "This is the peer reviewed version of the following article: EEspay, A. J., Bonato, P., Nahab, F. B., Maetzler, W., Dean, J. M., Klucken, J., ... Movement Disorders Society Task Force on Technology (2016). Technology in Parkinson's disease: challenges and opportunities. Movement Disorders, 31(9), 1272-1282, which has been published in final form at http://dx.doi.org/10.1002/mds.26642. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.",

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Espay, AJ, Bonato, P, Nahab, FB, Maetzler, W, Dean, JM, Klucken, J, Eskofier, BM, Merola, A, Horak, F, Lang, AE, Reilmann, R, Giuffrida, J, Nieuwboer, A, Horne, M, Little, MA, Litvan, I, Simuni, T, Dorsey, ER, Burack, MA, Kubota, K, Kamondi, A, Godinho, C, Daneault, J-F, Mitsi, G, Krinke, L, Hausdorff, JM, Bloem, BR, Papapetropoulos, S 2016, 'Technology in Parkinson's disease: challenges and opportunities', Movement Disorders, vol. 31, no. 9, pp. 1272-1282. https://doi.org/10.1002/mds.26642

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KW - eHealth

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KW - precision medicine

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Technology in Parkinson's disease: challenges and opportunities

Abstract

Bibliographical note

Keywords

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