Telomere length attrition, a marker of biological senescence, is inversely correlated with triglycerides and cholesterol in South Asian males with type 2 diabetes mellitus

Alison L. Harte, Nancy F. da Silva, Michelle A. Miller, Francesco P. Cappuccio, M. Ann Kelly, Joseph P. O'Hare, Anthony H. Barnett, Nasser M Al-Daghri, Omar Al-Attas, Majed Alokail, Shaun Sabico, Gyanendra Tripathi, Srikanth Bellary, Sudhesh Kumar, Philip G. McTernan

Research output: Contribution to journalArticle

Abstract

South Asians have a higher risk of type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD) than white Caucasians, for a given BMI. Premature biological ageing, assessed by reduction in telomere length (TL), may be mediated by factors resulting from altered metabolic profiles associated with obesity. We hypothesise that ethnicity and metabolic status represent detrimental factors contributing to premature biological ageing. Therefore we assessed TL in two South Asian, age and BMI-matched cohorts [T2DM (n = 142) versus non-T2DM (n = 76)] to determine the effects of BMI, gender, lipid and CVD profile on biological ageing. Genomic DNA was obtained from the UKADS cohort; biochemical and anthropometric data was collected and TL was measured by quantitative real-time PCR. Our findings indicated a gender-specific effect with reduced TL in T2DM men compared with non-T2DM men (P = 0.006). Additionally, in T2DM men, TL was inversely correlated with triglycerides and total cholesterol (r = -0.419, P <0.01; r = -0.443, P <0.01). In summary, TL was reduced amongst South Asian T2DM men and correlated with triglycerides and total cholesterol. This study highlights enhanced biological ageing among South Asian, T2DM men, which appears to be tracked by changes in lipids and BMI, suggesting that raised lipids and BMI may directly contribute to premature ageing.
Original languageEnglish
Article number895185
Number of pages7
JournalExperimental Diabetes Research
Volume2012
DOIs
Publication statusPublished - 2012

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Telomere
Type 2 Diabetes Mellitus
Triglycerides
Biomarkers
Cholesterol
Premature Aging
Lipids
Diabetes Mellitus
Cardiovascular Diseases
Metabolome
Length
Type 2 Diabetes
Attrition
Asia
Real-Time Polymerase Chain Reaction
Obesity
DNA

Bibliographical note

Copyright © 2012 Alison L. Harte et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Cite this

Harte, Alison L. ; da Silva, Nancy F. ; Miller, Michelle A. ; Cappuccio, Francesco P. ; Kelly, M. Ann ; O'Hare, Joseph P. ; Barnett, Anthony H. ; Al-Daghri, Nasser M ; Al-Attas, Omar ; Alokail, Majed ; Sabico, Shaun ; Tripathi, Gyanendra ; Bellary, Srikanth ; Kumar, Sudhesh ; McTernan, Philip G. / Telomere length attrition, a marker of biological senescence, is inversely correlated with triglycerides and cholesterol in South Asian males with type 2 diabetes mellitus. In: Experimental Diabetes Research. 2012 ; Vol. 2012.
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abstract = "South Asians have a higher risk of type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD) than white Caucasians, for a given BMI. Premature biological ageing, assessed by reduction in telomere length (TL), may be mediated by factors resulting from altered metabolic profiles associated with obesity. We hypothesise that ethnicity and metabolic status represent detrimental factors contributing to premature biological ageing. Therefore we assessed TL in two South Asian, age and BMI-matched cohorts [T2DM (n = 142) versus non-T2DM (n = 76)] to determine the effects of BMI, gender, lipid and CVD profile on biological ageing. Genomic DNA was obtained from the UKADS cohort; biochemical and anthropometric data was collected and TL was measured by quantitative real-time PCR. Our findings indicated a gender-specific effect with reduced TL in T2DM men compared with non-T2DM men (P = 0.006). Additionally, in T2DM men, TL was inversely correlated with triglycerides and total cholesterol (r = -0.419, P <0.01; r = -0.443, P <0.01). In summary, TL was reduced amongst South Asian T2DM men and correlated with triglycerides and total cholesterol. This study highlights enhanced biological ageing among South Asian, T2DM men, which appears to be tracked by changes in lipids and BMI, suggesting that raised lipids and BMI may directly contribute to premature ageing.",
author = "Harte, {Alison L.} and {da Silva}, {Nancy F.} and Miller, {Michelle A.} and Cappuccio, {Francesco P.} and Kelly, {M. Ann} and O'Hare, {Joseph P.} and Barnett, {Anthony H.} and Al-Daghri, {Nasser M} and Omar Al-Attas and Majed Alokail and Shaun Sabico and Gyanendra Tripathi and Srikanth Bellary and Sudhesh Kumar and McTernan, {Philip G.}",
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year = "2012",
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Harte, AL, da Silva, NF, Miller, MA, Cappuccio, FP, Kelly, MA, O'Hare, JP, Barnett, AH, Al-Daghri, NM, Al-Attas, O, Alokail, M, Sabico, S, Tripathi, G, Bellary, S, Kumar, S & McTernan, PG 2012, 'Telomere length attrition, a marker of biological senescence, is inversely correlated with triglycerides and cholesterol in South Asian males with type 2 diabetes mellitus', Experimental Diabetes Research, vol. 2012, 895185. https://doi.org/10.1155/2012/895185

Telomere length attrition, a marker of biological senescence, is inversely correlated with triglycerides and cholesterol in South Asian males with type 2 diabetes mellitus. / Harte, Alison L.; da Silva, Nancy F.; Miller, Michelle A.; Cappuccio, Francesco P.; Kelly, M. Ann; O'Hare, Joseph P.; Barnett, Anthony H.; Al-Daghri, Nasser M; Al-Attas, Omar; Alokail, Majed; Sabico, Shaun; Tripathi, Gyanendra; Bellary, Srikanth; Kumar, Sudhesh; McTernan, Philip G.

In: Experimental Diabetes Research, Vol. 2012, 895185, 2012.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Telomere length attrition, a marker of biological senescence, is inversely correlated with triglycerides and cholesterol in South Asian males with type 2 diabetes mellitus

AU - Harte, Alison L.

AU - da Silva, Nancy F.

AU - Miller, Michelle A.

AU - Cappuccio, Francesco P.

AU - Kelly, M. Ann

AU - O'Hare, Joseph P.

AU - Barnett, Anthony H.

AU - Al-Daghri, Nasser M

AU - Al-Attas, Omar

AU - Alokail, Majed

AU - Sabico, Shaun

AU - Tripathi, Gyanendra

AU - Bellary, Srikanth

AU - Kumar, Sudhesh

AU - McTernan, Philip G.

N1 - Copyright © 2012 Alison L. Harte et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PY - 2012

Y1 - 2012

N2 - South Asians have a higher risk of type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD) than white Caucasians, for a given BMI. Premature biological ageing, assessed by reduction in telomere length (TL), may be mediated by factors resulting from altered metabolic profiles associated with obesity. We hypothesise that ethnicity and metabolic status represent detrimental factors contributing to premature biological ageing. Therefore we assessed TL in two South Asian, age and BMI-matched cohorts [T2DM (n = 142) versus non-T2DM (n = 76)] to determine the effects of BMI, gender, lipid and CVD profile on biological ageing. Genomic DNA was obtained from the UKADS cohort; biochemical and anthropometric data was collected and TL was measured by quantitative real-time PCR. Our findings indicated a gender-specific effect with reduced TL in T2DM men compared with non-T2DM men (P = 0.006). Additionally, in T2DM men, TL was inversely correlated with triglycerides and total cholesterol (r = -0.419, P <0.01; r = -0.443, P <0.01). In summary, TL was reduced amongst South Asian T2DM men and correlated with triglycerides and total cholesterol. This study highlights enhanced biological ageing among South Asian, T2DM men, which appears to be tracked by changes in lipids and BMI, suggesting that raised lipids and BMI may directly contribute to premature ageing.

AB - South Asians have a higher risk of type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD) than white Caucasians, for a given BMI. Premature biological ageing, assessed by reduction in telomere length (TL), may be mediated by factors resulting from altered metabolic profiles associated with obesity. We hypothesise that ethnicity and metabolic status represent detrimental factors contributing to premature biological ageing. Therefore we assessed TL in two South Asian, age and BMI-matched cohorts [T2DM (n = 142) versus non-T2DM (n = 76)] to determine the effects of BMI, gender, lipid and CVD profile on biological ageing. Genomic DNA was obtained from the UKADS cohort; biochemical and anthropometric data was collected and TL was measured by quantitative real-time PCR. Our findings indicated a gender-specific effect with reduced TL in T2DM men compared with non-T2DM men (P = 0.006). Additionally, in T2DM men, TL was inversely correlated with triglycerides and total cholesterol (r = -0.419, P <0.01; r = -0.443, P <0.01). In summary, TL was reduced amongst South Asian T2DM men and correlated with triglycerides and total cholesterol. This study highlights enhanced biological ageing among South Asian, T2DM men, which appears to be tracked by changes in lipids and BMI, suggesting that raised lipids and BMI may directly contribute to premature ageing.

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