Temperature-Regulating Phase Change Fiber Scaffold Toward Mild Photothermal–Chemotherapy

Lei Chen; Xiaoqing Sun; Kai Cheng; Paul D. Topham; Mengmeng Xu; Yifan Jia; Donghua Dong; Shuo Wang; Yuan Liu; Linge Wang; Qianqian Yu

doi:10.1007/s42765-022-00199-8

Temperature-Regulating Phase Change Fiber Scaffold Toward Mild Photothermal–Chemotherapy

Lei Chen, Xiaoqing Sun, Kai Cheng, Paul D. Topham, Mengmeng Xu, Yifan Jia, Donghua Dong, Shuo Wang, Yuan Liu, Linge Wang^*, Qianqian Yu

^*Corresponding author for this work

Aston Polymer Research Group

Research output: Contribution to journal › Article › peer-review

Abstract

Photothermal therapy (PTT) is a treatment that increases the temperature of tumors to 42–48 °C, or even higher for tumor ablation. PTT has sparked a lot of attention due to its ability to induce apoptosis or increase sensitivity to chemotherapy. Excessive heat not only kills the tumor cells, but also damages the surrounding healthy tissue, reducing therapeutic accuracy and increasing the possible side effects. Herein, a phase change fiber (PCF) scaffold serving as a thermal trigger in mild photothermal–chemo tumor therapy is developed to regulate temperature and control drug release. These prepared PCFs, comprised of hollow carbon fibers (HCFs) loaded with lauric acid as a phase change material (PCM), can effectively store and release any excess heat generated by irradiating with a near-infrared (NIR) laser through the reversible solid–liquid transition process of the PCM. With this feature, the optimal PTT temperature of implanted PCF-based composite scaffolds was identified for tumor therapy with minimal normal tissue damage. In addition, controlled release of chemotherapeutic drugs and heat shock protein (HSP) inhibitors from the PCF-based composite scaffolds have been shown to improve the efficacy of mild PTT. The developed PCF-based scaffold sheds light on the development of a new generation of therapeutic scaffolds for thermal therapy. Graphical Abstract: [Figure not available: see fulltext.]

Original language	English
Pages (from-to)	1669-1684
Journal	Advanced Fiber Materials
Volume	4
Issue number	6
Early online date	29 Sept 2022
DOIs	https://doi.org/10.1007/s42765-022-00199-8
Publication status	Published - Dec 2022

Bibliographical note

© Donghua University, Shanghai, China 2022. This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use [https://www.springernature.com/gp/open-research/policies/accepted-manuscript-terms], but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/0.1007/s42765-022-00199-8

Funding Information:
The authors thank the financial support from National Key R&D Program of China (No. 2017YFC1105003, 2021YFB3802700), National Natural Science Foundation of China (No. 21807046), Guangdong Project (No. 2016ZT06C322), National Natural Science Foundation of Guangdong (No. 2020A151501744), Science and Technology Program of Guangzhou (No. 202102020759), Guangdong Basic and Applied Basic Research Foundation (No. 2021A1515111174), and Overseas Expertise Introduction Center for Discipline Innovation (“111 Center”).

Keywords

Controlled drug release
Heat shock protein
Mild photothermal–chemotherapy
Phase change fiber
Temperature regulation

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10.1007/s42765-022-00199-8

Chen Sun Cheng Topham et al_Accepted_manuscript_Temperature_regulating Phase Change Fiber Scaffold towards Mild Photothermal_chemotherapy
© Donghua University, Shanghai, China 2022. This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use [https://www.springernature.com/gp/open-research/policies/accepted-manuscript-terms], but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/0.1007/s42765-022-00199-8
Accepted author manuscript, 1.58 MBLicence: Other

Cite this

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title = "Temperature-Regulating Phase Change Fiber Scaffold Toward Mild Photothermal–Chemotherapy",

abstract = "Photothermal therapy (PTT) is a treatment that increases the temperature of tumors to 42–48 °C, or even higher for tumor ablation. PTT has sparked a lot of attention due to its ability to induce apoptosis or increase sensitivity to chemotherapy. Excessive heat not only kills the tumor cells, but also damages the surrounding healthy tissue, reducing therapeutic accuracy and increasing the possible side effects. Herein, a phase change fiber (PCF) scaffold serving as a thermal trigger in mild photothermal–chemo tumor therapy is developed to regulate temperature and control drug release. These prepared PCFs, comprised of hollow carbon fibers (HCFs) loaded with lauric acid as a phase change material (PCM), can effectively store and release any excess heat generated by irradiating with a near-infrared (NIR) laser through the reversible solid–liquid transition process of the PCM. With this feature, the optimal PTT temperature of implanted PCF-based composite scaffolds was identified for tumor therapy with minimal normal tissue damage. In addition, controlled release of chemotherapeutic drugs and heat shock protein (HSP) inhibitors from the PCF-based composite scaffolds have been shown to improve the efficacy of mild PTT. The developed PCF-based scaffold sheds light on the development of a new generation of therapeutic scaffolds for thermal therapy. Graphical Abstract: [Figure not available: see fulltext.]",

keywords = "Controlled drug release, Heat shock protein, Mild photothermal–chemotherapy, Phase change fiber, Temperature regulation",

author = "Lei Chen and Xiaoqing Sun and Kai Cheng and Topham, {Paul D.} and Mengmeng Xu and Yifan Jia and Donghua Dong and Shuo Wang and Yuan Liu and Linge Wang and Qianqian Yu",

note = "{\textcopyright} Donghua University, Shanghai, China 2022. This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature{\textquoteright}s AM terms of use [https://www.springernature.com/gp/open-research/policies/accepted-manuscript-terms], but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/0.1007/s42765-022-00199-8 Funding Information: The authors thank the financial support from National Key R&D Program of China (No. 2017YFC1105003, 2021YFB3802700), National Natural Science Foundation of China (No. 21807046), Guangdong Project (No. 2016ZT06C322), National Natural Science Foundation of Guangdong (No. 2020A151501744), Science and Technology Program of Guangzhou (No. 202102020759), Guangdong Basic and Applied Basic Research Foundation (No. 2021A1515111174), and Overseas Expertise Introduction Center for Discipline Innovation (“111 Center”). ",

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AU - Chen, Lei

AU - Sun, Xiaoqing

AU - Cheng, Kai

AU - Topham, Paul D.

AU - Xu, Mengmeng

AU - Jia, Yifan

AU - Dong, Donghua

AU - Wang, Shuo

AU - Liu, Yuan

AU - Wang, Linge

AU - Yu, Qianqian

N1 - © Donghua University, Shanghai, China 2022. This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use [https://www.springernature.com/gp/open-research/policies/accepted-manuscript-terms], but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/0.1007/s42765-022-00199-8 Funding Information: The authors thank the financial support from National Key R&D Program of China (No. 2017YFC1105003, 2021YFB3802700), National Natural Science Foundation of China (No. 21807046), Guangdong Project (No. 2016ZT06C322), National Natural Science Foundation of Guangdong (No. 2020A151501744), Science and Technology Program of Guangzhou (No. 202102020759), Guangdong Basic and Applied Basic Research Foundation (No. 2021A1515111174), and Overseas Expertise Introduction Center for Discipline Innovation (“111 Center”).

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N2 - Photothermal therapy (PTT) is a treatment that increases the temperature of tumors to 42–48 °C, or even higher for tumor ablation. PTT has sparked a lot of attention due to its ability to induce apoptosis or increase sensitivity to chemotherapy. Excessive heat not only kills the tumor cells, but also damages the surrounding healthy tissue, reducing therapeutic accuracy and increasing the possible side effects. Herein, a phase change fiber (PCF) scaffold serving as a thermal trigger in mild photothermal–chemo tumor therapy is developed to regulate temperature and control drug release. These prepared PCFs, comprised of hollow carbon fibers (HCFs) loaded with lauric acid as a phase change material (PCM), can effectively store and release any excess heat generated by irradiating with a near-infrared (NIR) laser through the reversible solid–liquid transition process of the PCM. With this feature, the optimal PTT temperature of implanted PCF-based composite scaffolds was identified for tumor therapy with minimal normal tissue damage. In addition, controlled release of chemotherapeutic drugs and heat shock protein (HSP) inhibitors from the PCF-based composite scaffolds have been shown to improve the efficacy of mild PTT. The developed PCF-based scaffold sheds light on the development of a new generation of therapeutic scaffolds for thermal therapy. Graphical Abstract: [Figure not available: see fulltext.]

AB - Photothermal therapy (PTT) is a treatment that increases the temperature of tumors to 42–48 °C, or even higher for tumor ablation. PTT has sparked a lot of attention due to its ability to induce apoptosis or increase sensitivity to chemotherapy. Excessive heat not only kills the tumor cells, but also damages the surrounding healthy tissue, reducing therapeutic accuracy and increasing the possible side effects. Herein, a phase change fiber (PCF) scaffold serving as a thermal trigger in mild photothermal–chemo tumor therapy is developed to regulate temperature and control drug release. These prepared PCFs, comprised of hollow carbon fibers (HCFs) loaded with lauric acid as a phase change material (PCM), can effectively store and release any excess heat generated by irradiating with a near-infrared (NIR) laser through the reversible solid–liquid transition process of the PCM. With this feature, the optimal PTT temperature of implanted PCF-based composite scaffolds was identified for tumor therapy with minimal normal tissue damage. In addition, controlled release of chemotherapeutic drugs and heat shock protein (HSP) inhibitors from the PCF-based composite scaffolds have been shown to improve the efficacy of mild PTT. The developed PCF-based scaffold sheds light on the development of a new generation of therapeutic scaffolds for thermal therapy. Graphical Abstract: [Figure not available: see fulltext.]

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JO - Advanced Fiber Materials

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ER -

Temperature-Regulating Phase Change Fiber Scaffold Toward Mild Photothermal–Chemotherapy

Abstract

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Keywords

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