Temperature-Regulating Phase Change Fiber Scaffold Toward Mild Photothermal–Chemotherapy

Lei Chen, Xiaoqing Sun, Kai Cheng, Paul D. Topham, Mengmeng Xu, Yifan Jia, Donghua Dong, Shuo Wang, Yuan Liu, Linge Wang*, Qianqian Yu

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Photothermal therapy (PTT) is a treatment that increases the temperature of tumors to 42–48 °C, or even higher for tumor ablation. PTT has sparked a lot of attention due to its ability to induce apoptosis or increase sensitivity to chemotherapy. Excessive heat not only kills the tumor cells, but also damages the surrounding healthy tissue, reducing therapeutic accuracy and increasing the possible side effects. Herein, a phase change fiber (PCF) scaffold serving as a thermal trigger in mild photothermal–chemo tumor therapy is developed to regulate temperature and control drug release. These prepared PCFs, comprised of hollow carbon fibers (HCFs) loaded with lauric acid as a phase change material (PCM), can effectively store and release any excess heat generated by irradiating with a near-infrared (NIR) laser through the reversible solid–liquid transition process of the PCM. With this feature, the optimal PTT temperature of implanted PCF-based composite scaffolds was identified for tumor therapy with minimal normal tissue damage. In addition, controlled release of chemotherapeutic drugs and heat shock protein (HSP) inhibitors from the PCF-based composite scaffolds have been shown to improve the efficacy of mild PTT. The developed PCF-based scaffold sheds light on the development of a new generation of therapeutic scaffolds for thermal therapy. Graphical Abstract: [Figure not available: see fulltext.]

Original languageEnglish
JournalAdvanced Fiber Materials
Early online date29 Sep 2022
DOIs
Publication statusE-pub ahead of print - 29 Sep 2022

Bibliographical note

© Donghua University, Shanghai, China 2022. This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use [https://www.springernature.com/gp/open-research/policies/accepted-manuscript-terms], but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/0.1007/s42765-022-00199-8

Funding Information:
The authors thank the financial support from National Key R&D Program of China (No. 2017YFC1105003, 2021YFB3802700), National Natural Science Foundation of China (No. 21807046), Guangdong Project (No. 2016ZT06C322), National Natural Science Foundation of Guangdong (No. 2020A151501744), Science and Technology Program of Guangzhou (No. 202102020759), Guangdong Basic and Applied Basic Research Foundation (No. 2021A1515111174), and Overseas Expertise Introduction Center for Discipline Innovation (“111 Center”).

Keywords

  • Controlled drug release
  • Heat shock protein
  • Mild photothermal–chemotherapy
  • Phase change fiber
  • Temperature regulation

Fingerprint

Dive into the research topics of 'Temperature-Regulating Phase Change Fiber Scaffold Toward Mild Photothermal–Chemotherapy'. Together they form a unique fingerprint.

Cite this