Testing a Fine-Needle Optical Probe for Recording Changes in the Fluorescence of Coenzymes of Cellular Respiration

K. Yu Kandurova*, E. V. Potapova, E. A. Zherebtsov, V. V. Dremin, E. S. Seryogina, A. Yu Vinokurov, A. V. Mamoshin, A. V. Borsukov, Yu V. Ivanov, A. V. Dunaev

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

A device for optical biopsy with a fluorescence spectroscopy channel and a fine-needle optical probe for use in fine-needle aspiration biopsy of liver tumors is described. To test the developed device, experimental measurements of the fluorescence of internal organs of a laboratory rat were carried out in vivo while exposing the tissue surface to mitochondrial uncoupling to induce changes in cell respiration. The results of the model experiment showed the ability of the developed channel to detect changes in fluorescence due to changes in the processes of oxidative phosphorylation of mitochondria.

Original languageEnglish
Pages (from-to)742-751
Number of pages10
JournalOptics and Spectroscopy
Volume128
Issue number6
DOIs
Publication statusPublished - 15 Jul 2020

Bibliographical note

Funding Information:
This work was supported by the Russian Science Foundation, project no. 18-15-00201.

Publisher Copyright:
© 2020, Pleiades Publishing, Ltd.

Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.

Keywords

  • FAD
  • fluorescence spectroscopy
  • mitochondrial uncouplers
  • NADH
  • optical biopsy

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