A device for optical biopsy with a fluorescence spectroscopy channel and a fine-needle optical probe for use in fine-needle aspiration biopsy of liver tumors is described. To test the developed device, experimental measurements of the fluorescence of internal organs of a laboratory rat were carried out in vivo while exposing the tissue surface to mitochondrial uncoupling to induce changes in cell respiration. The results of the model experiment showed the ability of the developed channel to detect changes in fluorescence due to changes in the processes of oxidative phosphorylation of mitochondria.
Bibliographical noteFunding Information:
This work was supported by the Russian Science Foundation, project no. 18-15-00201.
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- fluorescence spectroscopy
- mitochondrial uncouplers
- optical biopsy