Tetrahydrobiopterin is the cofactor required for the biosynthesis of the neurotransmitters and neuromodulators dopamine, noradrenaline and serotonin. The results show that in SDAT there is decreased conversion of dihydroneopterin triphosphate to tetrahydrobiopterin. Further measurements on strictly age-matched SDAT subjects and controls have confirmed the trends in this investigation.
|Number of pages||2|
|Journal||Biochemical Society Transactions|
|Publication status||Published - 1987|
Bibliographical note621st Meeting of the Biochemical Society, 1987, London (UK).
- neuromodulators dopamine