Tetrahydrobiopterin metabolism in senile dementia of the Alzheimer type (SDAT)

S.A. Jones, Richard A. Armstrong, J.A. Blair, R.J. Leeming, C. Chaudhry, C. Swade, A. Coppen

Research output: Contribution to journalConference abstractpeer-review


Tetrahydrobiopterin is the cofactor required for the biosynthesis of the neurotransmitters and neuromodulators dopamine, noradrenaline and serotonin. The results show that in SDAT there is decreased conversion of dihydroneopterin triphosphate to tetrahydrobiopterin. Further measurements on strictly age-matched SDAT subjects and controls have confirmed the trends in this investigation.
Original languageEnglish
Pages (from-to)713-714
Number of pages2
JournalBiochemical Society Transactions
Issue number4
Publication statusPublished - 1987

Bibliographical note

621st Meeting of the Biochemical Society, 1987, London (UK).


  • tetrahydrobiopterin
  • biosynthesis
  • neurotransmitters
  • neuromodulators dopamine
  • noradrenaline
  • serotonin


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