Tetrahydrobiopterin metabolism in senile dementia of the Alzheimer type (SDAT)

S.A. Jones; Richard A. Armstrong; J.A. Blair; R.J. Leeming; C. Chaudhry; C. Swade; A. Coppen

Tetrahydrobiopterin metabolism in senile dementia of the Alzheimer type (SDAT)

S.A. Jones, Richard A. Armstrong, J.A. Blair, R.J. Leeming, C. Chaudhry, C. Swade, A. Coppen

Research output: Contribution to journal › Conference abstract › peer-review

Abstract

Tetrahydrobiopterin is the cofactor required for the biosynthesis of the neurotransmitters and neuromodulators dopamine, noradrenaline and serotonin. The results show that in SDAT there is decreased conversion of dihydroneopterin triphosphate to tetrahydrobiopterin. Further measurements on strictly age-matched SDAT subjects and controls have confirmed the trends in this investigation.

Original language	English
Pages (from-to)	713-714
Number of pages	2
Journal	Biochemical Society Transactions
Volume	15
Issue number	4
Publication status	Published - 1987

Bibliographical note

621st Meeting of the Biochemical Society, 1987, London (UK).

Keywords

tetrahydrobiopterin
biosynthesis
neurotransmitters
neuromodulators dopamine
noradrenaline
serotonin

Cite this

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title = "Tetrahydrobiopterin metabolism in senile dementia of the Alzheimer type (SDAT)",

abstract = "Tetrahydrobiopterin is the cofactor required for the biosynthesis of the neurotransmitters and neuromodulators dopamine, noradrenaline and serotonin. The results show that in SDAT there is decreased conversion of dihydroneopterin triphosphate to tetrahydrobiopterin. Further measurements on strictly age-matched SDAT subjects and controls have confirmed the trends in this investigation.",

keywords = "tetrahydrobiopterin, biosynthesis, neurotransmitters, neuromodulators dopamine, noradrenaline, serotonin",

author = "S.A. Jones and Armstrong, {Richard A.} and J.A. Blair and R.J. Leeming and C. Chaudhry and C. Swade and A. Coppen",

note = "621st Meeting of the Biochemical Society, 1987, London (UK).",

year = "1987",

language = "English",

volume = "15",

pages = "713--714",

journal = "Biochemical Society Transactions",

issn = "0300-5127",

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number = "4",

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TY - JOUR

T1 - Tetrahydrobiopterin metabolism in senile dementia of the Alzheimer type (SDAT)

AU - Jones, S.A.

AU - Armstrong, Richard A.

AU - Blair, J.A.

AU - Leeming, R.J.

AU - Chaudhry, C.

AU - Swade, C.

AU - Coppen, A.

N1 - 621st Meeting of the Biochemical Society, 1987, London (UK).

PY - 1987

Y1 - 1987

N2 - Tetrahydrobiopterin is the cofactor required for the biosynthesis of the neurotransmitters and neuromodulators dopamine, noradrenaline and serotonin. The results show that in SDAT there is decreased conversion of dihydroneopterin triphosphate to tetrahydrobiopterin. Further measurements on strictly age-matched SDAT subjects and controls have confirmed the trends in this investigation.

AB - Tetrahydrobiopterin is the cofactor required for the biosynthesis of the neurotransmitters and neuromodulators dopamine, noradrenaline and serotonin. The results show that in SDAT there is decreased conversion of dihydroneopterin triphosphate to tetrahydrobiopterin. Further measurements on strictly age-matched SDAT subjects and controls have confirmed the trends in this investigation.

KW - tetrahydrobiopterin

KW - biosynthesis

KW - neurotransmitters

KW - neuromodulators dopamine

KW - noradrenaline

KW - serotonin

UR - http://www.biochemsoctrans.org/content/15/4/713

M3 - Conference abstract

SN - 0300-5127

VL - 15

SP - 713

EP - 714

JO - Biochemical Society Transactions

JF - Biochemical Society Transactions

IS - 4

ER -

Tetrahydrobiopterin metabolism in senile dementia of the Alzheimer type (SDAT)

Abstract

Bibliographical note

Keywords

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