Tetrahydrobiopterin metabolism in senile dementia of the Alzheimer type (SDAT)

S.A. Jones, Richard A. Armstrong, J.A. Blair, R.J. Leeming, C. Chaudhry, C. Swade, A. Coppen

Research output: Contribution to journalMeeting abstract

Abstract

Tetrahydrobiopterin is the cofactor required for the biosynthesis of the neurotransmitters and neuromodulators dopamine, noradrenaline and serotonin. The results show that in SDAT there is decreased conversion of dihydroneopterin triphosphate to tetrahydrobiopterin. Further measurements on strictly age-matched SDAT subjects and controls have confirmed the trends in this investigation.
Original languageEnglish
Pages (from-to)713-714
Number of pages2
JournalBiochemical Society Transactions
Volume15
Issue number4
Publication statusPublished - 1987

Fingerprint

Metabolism
Neurotransmitter Agents
Alzheimer Disease
Biosynthesis
Dopamine
Serotonin
Norepinephrine
sapropterin
dihydroneopterin triphosphate

Bibliographical note

621st Meeting of the Biochemical Society, 1987, London (UK).

Keywords

  • tetrahydrobiopterin
  • biosynthesis
  • neurotransmitters
  • neuromodulators dopamine
  • noradrenaline
  • serotonin

Cite this

Jones, S. A., Armstrong, R. A., Blair, J. A., Leeming, R. J., Chaudhry, C., Swade, C., & Coppen, A. (1987). Tetrahydrobiopterin metabolism in senile dementia of the Alzheimer type (SDAT). Biochemical Society Transactions, 15(4), 713-714.
Jones, S.A. ; Armstrong, Richard A. ; Blair, J.A. ; Leeming, R.J. ; Chaudhry, C. ; Swade, C. ; Coppen, A. / Tetrahydrobiopterin metabolism in senile dementia of the Alzheimer type (SDAT). In: Biochemical Society Transactions. 1987 ; Vol. 15, No. 4. pp. 713-714.
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Jones, SA, Armstrong, RA, Blair, JA, Leeming, RJ, Chaudhry, C, Swade, C & Coppen, A 1987, 'Tetrahydrobiopterin metabolism in senile dementia of the Alzheimer type (SDAT)', Biochemical Society Transactions, vol. 15, no. 4, pp. 713-714.

Tetrahydrobiopterin metabolism in senile dementia of the Alzheimer type (SDAT). / Jones, S.A.; Armstrong, Richard A.; Blair, J.A.; Leeming, R.J.; Chaudhry, C.; Swade, C.; Coppen, A.

In: Biochemical Society Transactions, Vol. 15, No. 4, 1987, p. 713-714.

Research output: Contribution to journalMeeting abstract

TY - JOUR

T1 - Tetrahydrobiopterin metabolism in senile dementia of the Alzheimer type (SDAT)

AU - Jones, S.A.

AU - Armstrong, Richard A.

AU - Blair, J.A.

AU - Leeming, R.J.

AU - Chaudhry, C.

AU - Swade, C.

AU - Coppen, A.

N1 - 621st Meeting of the Biochemical Society, 1987, London (UK).

PY - 1987

Y1 - 1987

N2 - Tetrahydrobiopterin is the cofactor required for the biosynthesis of the neurotransmitters and neuromodulators dopamine, noradrenaline and serotonin. The results show that in SDAT there is decreased conversion of dihydroneopterin triphosphate to tetrahydrobiopterin. Further measurements on strictly age-matched SDAT subjects and controls have confirmed the trends in this investigation.

AB - Tetrahydrobiopterin is the cofactor required for the biosynthesis of the neurotransmitters and neuromodulators dopamine, noradrenaline and serotonin. The results show that in SDAT there is decreased conversion of dihydroneopterin triphosphate to tetrahydrobiopterin. Further measurements on strictly age-matched SDAT subjects and controls have confirmed the trends in this investigation.

KW - tetrahydrobiopterin

KW - biosynthesis

KW - neurotransmitters

KW - neuromodulators dopamine

KW - noradrenaline

KW - serotonin

UR - http://www.biochemsoctrans.org/content/15/4/713

M3 - Meeting abstract

VL - 15

SP - 713

EP - 714

JO - Biochemical Society Transactions

JF - Biochemical Society Transactions

SN - 0300-5127

IS - 4

ER -

Jones SA, Armstrong RA, Blair JA, Leeming RJ, Chaudhry C, Swade C et al. Tetrahydrobiopterin metabolism in senile dementia of the Alzheimer type (SDAT). Biochemical Society Transactions. 1987;15(4):713-714.