TG2: a credible therapeutic target in fibrotic diseasedue to its multifunctional roles

Martin Griffin, Zhuo Wang, Thomas Thibault, Colin Murdoch, Daniel Rathbone

Research output: Contribution to journalMeeting abstract

Abstract

The role of TG2 in fibrosis is reported to be related to two important effects. The first in mediating the deposition and accumulation of the fibrotic extracellular matrix (ECM) via its cross-linking of proteins like fibronectin, collagen I and collagen III; and the second, the activation of latent matrix bound TGFβ1. We report here that the role of TG2 in fibrosis progression can be much more complex.
We also report a new family of TG2-specific inhibitors that can not only inhibit protein cross-linking, but also regulate other functions of TG2, thus increasing their potency which can be demonstrated by their effectiveness in inhibiting fibrosis in two different fibrotic in vivo models.
Original languageEnglish
Pages (from-to)1629
Number of pages1
JournalAmino Acids
Volume47
Issue number8
Early online date14 Jul 2015
DOIs
Publication statusPublished - 31 Aug 2015
Event14th International Congress on Amino Acids, Peptides and Proteins - Vienna, Austria
Duration: 3 Aug 20157 Aug 2015

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Fibrosis
Collagen
Fibronectins
Proteins
Chemical activation
Extracellular Matrix
Therapeutics

Bibliographical note

Abstracts presented at the 14th International Congress on Amino Acids, Peptides and Proteins, Vienna (AT), August 3–7, 2015.

Cite this

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title = "TG2: a credible therapeutic target in fibrotic diseasedue to its multifunctional roles",
abstract = "The role of TG2 in fibrosis is reported to be related to two important effects. The first in mediating the deposition and accumulation of the fibrotic extracellular matrix (ECM) via its cross-linking of proteins like fibronectin, collagen I and collagen III; and the second, the activation of latent matrix bound TGFβ1. We report here that the role of TG2 in fibrosis progression can be much more complex. We also report a new family of TG2-specific inhibitors that can not only inhibit protein cross-linking, but also regulate other functions of TG2, thus increasing their potency which can be demonstrated by their effectiveness in inhibiting fibrosis in two different fibrotic in vivo models.",
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TG2: a credible therapeutic target in fibrotic diseasedue to its multifunctional roles. / Griffin, Martin; Wang, Zhuo; Thibault, Thomas; Murdoch, Colin; Rathbone, Daniel.

In: Amino Acids, Vol. 47, No. 8, 31.08.2015, p. 1629.

Research output: Contribution to journalMeeting abstract

TY - JOUR

T1 - TG2: a credible therapeutic target in fibrotic diseasedue to its multifunctional roles

AU - Griffin, Martin

AU - Wang, Zhuo

AU - Thibault, Thomas

AU - Murdoch, Colin

AU - Rathbone, Daniel

N1 - Abstracts presented at the 14th International Congress on Amino Acids, Peptides and Proteins, Vienna (AT), August 3–7, 2015.

PY - 2015/8/31

Y1 - 2015/8/31

N2 - The role of TG2 in fibrosis is reported to be related to two important effects. The first in mediating the deposition and accumulation of the fibrotic extracellular matrix (ECM) via its cross-linking of proteins like fibronectin, collagen I and collagen III; and the second, the activation of latent matrix bound TGFβ1. We report here that the role of TG2 in fibrosis progression can be much more complex. We also report a new family of TG2-specific inhibitors that can not only inhibit protein cross-linking, but also regulate other functions of TG2, thus increasing their potency which can be demonstrated by their effectiveness in inhibiting fibrosis in two different fibrotic in vivo models.

AB - The role of TG2 in fibrosis is reported to be related to two important effects. The first in mediating the deposition and accumulation of the fibrotic extracellular matrix (ECM) via its cross-linking of proteins like fibronectin, collagen I and collagen III; and the second, the activation of latent matrix bound TGFβ1. We report here that the role of TG2 in fibrosis progression can be much more complex. We also report a new family of TG2-specific inhibitors that can not only inhibit protein cross-linking, but also regulate other functions of TG2, thus increasing their potency which can be demonstrated by their effectiveness in inhibiting fibrosis in two different fibrotic in vivo models.

U2 - 10.1007/s00726-015-2016-z

DO - 10.1007/s00726-015-2016-z

M3 - Meeting abstract

VL - 47

SP - 1629

JO - Amino Acids

JF - Amino Acids

SN - 0939-4451

IS - 8

ER -