Abstract
The CGRP (calcitonin gene-related peptide) receptor is a family B GPCR (G-protein-coupled receptor). It consists of a GPCR, CLR (calcitonin receptor-like receptor) and an accessory protein, RAMP1 (receptor activity modifying protein 1). RAMP1 is needed for CGRP binding and also cell-surface expression of CLR. CLR is an example of a family B GPCR. Unlike family A GPCRs, little is known about how these receptors are activated by their endogenous ligands. This review considers what is known about the activation of family B GPCRs and then considers how this might be applied to CLR, particularly in light of new knowledge of the crystal structures of family A GPCRs.
Original language | English |
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Pages (from-to) | 180-184 |
Number of pages | 5 |
Journal | Biochemical Society Transactions |
Volume | 41 |
Issue number | 1 |
DOIs | |
Publication status | Published - Feb 2013 |
Bibliographical note
Funding: Wellcome Trust [091496]; Medical Research Council [G1001812]Keywords
- alanine scan
- family A GPCRs
- family B GPCRs
- mutagenesis
- secretin-like GPCR
- structure–activity relationship