The activation of the CGRP receptor

James Barwell, Mark Wheatley, Alex C. Conner, Bruck Taddese, Shabana Vohra, Christopher A. Reynolds, David R. Poyner

Research output: Contribution to journalArticle

Abstract

The CGRP (calcitonin gene-related peptide) receptor is a family B GPCR (G-protein-coupled receptor). It consists of a GPCR, CLR (calcitonin receptor-like receptor) and an accessory protein, RAMP1 (receptor activity modifying protein 1). RAMP1 is needed for CGRP binding and also cell-surface expression of CLR. CLR is an example of a family B GPCR. Unlike family A GPCRs, little is known about how these receptors are activated by their endogenous ligands. This review considers what is known about the activation of family B GPCRs and then considers how this might be applied to CLR, particularly in light of new knowledge of the crystal structures of family A GPCRs.
Original languageEnglish
Pages (from-to)180-184
Number of pages5
JournalBiochemical Society Transactions
Volume41
Issue number1
DOIs
Publication statusPublished - Feb 2013

Fingerprint

Calcitonin Receptor-Like Protein
Calcitonin Gene-Related Peptide Receptors
Receptor Activity-Modifying Protein 1
G-Protein-Coupled Receptors
Chemical activation
Calcitonin Gene-Related Peptide
Accessories
Crystal structure
Ligands
Proteins

Bibliographical note

Funding: Wellcome Trust [091496]; Medical Research Council [G1001812]

Keywords

  • alanine scan
  • family A GPCRs
  • family B GPCRs
  • mutagenesis
  • secretin-like GPCR
  • structure–activity relationship

Cite this

Barwell, J., Wheatley, M., Conner, A. C., Taddese, B., Vohra, S., Reynolds, C. A., & Poyner, D. R. (2013). The activation of the CGRP receptor. Biochemical Society Transactions, 41(1), 180-184. https://doi.org/10.1042/BST20120251
Barwell, James ; Wheatley, Mark ; Conner, Alex C. ; Taddese, Bruck ; Vohra, Shabana ; Reynolds, Christopher A. ; Poyner, David R. / The activation of the CGRP receptor. In: Biochemical Society Transactions. 2013 ; Vol. 41, No. 1. pp. 180-184.
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Barwell, J, Wheatley, M, Conner, AC, Taddese, B, Vohra, S, Reynolds, CA & Poyner, DR 2013, 'The activation of the CGRP receptor', Biochemical Society Transactions, vol. 41, no. 1, pp. 180-184. https://doi.org/10.1042/BST20120251

The activation of the CGRP receptor. / Barwell, James; Wheatley, Mark; Conner, Alex C.; Taddese, Bruck; Vohra, Shabana; Reynolds, Christopher A.; Poyner, David R.

In: Biochemical Society Transactions, Vol. 41, No. 1, 02.2013, p. 180-184.

Research output: Contribution to journalArticle

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Barwell J, Wheatley M, Conner AC, Taddese B, Vohra S, Reynolds CA et al. The activation of the CGRP receptor. Biochemical Society Transactions. 2013 Feb;41(1):180-184. https://doi.org/10.1042/BST20120251