The activation of the CGRP receptor

James Barwell, Mark Wheatley, Alex C. Conner, Bruck Taddese, Shabana Vohra, Christopher A. Reynolds, David R. Poyner

Research output: Contribution to journalArticlepeer-review


The CGRP (calcitonin gene-related peptide) receptor is a family B GPCR (G-protein-coupled receptor). It consists of a GPCR, CLR (calcitonin receptor-like receptor) and an accessory protein, RAMP1 (receptor activity modifying protein 1). RAMP1 is needed for CGRP binding and also cell-surface expression of CLR. CLR is an example of a family B GPCR. Unlike family A GPCRs, little is known about how these receptors are activated by their endogenous ligands. This review considers what is known about the activation of family B GPCRs and then considers how this might be applied to CLR, particularly in light of new knowledge of the crystal structures of family A GPCRs.
Original languageEnglish
Pages (from-to)180-184
Number of pages5
JournalBiochemical Society Transactions
Issue number1
Publication statusPublished - Feb 2013

Bibliographical note

Funding: Wellcome Trust [091496]; Medical Research Council [G1001812]


  • alanine scan
  • family A GPCRs
  • family B GPCRs
  • mutagenesis
  • secretin-like GPCR
  • structure–activity relationship


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