The ageing ocular surface: challenges for biomaterials design and function

A. Mann*, D. Campbell, B.J. Tighe

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Changing demographics and in particular an increasingly ageing population, in combination with improved longevity, will have a major impact on changing the face of human diseases and likewise the demand for appropriate biomaterials. The ocular surface is a multifaceted system that combines to create a unique mucosal surface, which includes the cornea, conjunctiva, sclera and lids of the eye. Physical parameters such as the eyelids and eyelashes, combined with the numerous secretory glands that produce the complex tear film, act together to protect and maintain the cornea. Unfortunately an ageing tear film and lacrimal functional unit can lead to impairment of this magnificently orchestrated structure. No single mechanism or modification is responsible but, whatever the cause, the consequence is a reduction in tear stability. An uncompromised tear film is fundamental to a healthy ocular surface. In the face of progressively changing demographics and consequent requirements for medical intervention and medical device developments, it is important to understand what effects the ageing process has on these anterior ocular structures.

Original languageEnglish
Title of host publicationBiomaterials and regenerative medicine in ophthalmology
EditorsTraian V. Chirila, Damien G. Harkin
Place of PublicationLondon (UK)
PublisherWoodhead
Pages17-43
Number of pages27
Edition2nd
ISBN (Electronic)978-0-08-100184-4
ISBN (Print)978-0-08-100147-9
DOIs
Publication statusPublished - 21 Apr 2016

Publication series

NameWoodhead Publishing Series in Biomaterials
PublisherWoodhead Publishing
Number112

Keywords

  • ageing vision
  • contact lenses
  • lacrimal functional unit
  • tear film
  • therapeutic bandage lenses

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  • Research Output

    Ocular biotribology and the contact lens: Surface interactions and ocular response

    Mann, A. & Tighe, B. J., 21 Apr 2016, Biomaterials and regenerative medicine in ophthalmology. Chirila, T. V. & Harkin, D. G. (eds.). 2nd ed. London (UK): Woodhead, p. 45-74 30 p. (Woodhead Publishing Series in Biomaterials; no. 112).

    Research output: Chapter in Book/Report/Conference proceedingChapter

  • Physicochemical properties of hydrogels for use in ophthalmology

    Tighe, B. J. & Mann, A., 21 Apr 2016, Biomaterials and regenerative medicine in ophthalmology. Chirila, T. V. & Harkin, D. G. (eds.). 2nd ed. London (UK): Woodhead, p. 75-100 26 p. (Woodhead Publishing Series in Biomaterials; no. 112).

    Research output: Chapter in Book/Report/Conference proceedingChapter

  • The development of biomaterials for contact lens applications: effects of wear modality on materials design

    Tighe, B. J. & Mann, A., 21 Apr 2016, Biomaterials and regenerative medicine in ophthalmology. Chirila, T. V. & Harkin, D. G. (eds.). 2nd ed. London (UK): Woodhead, p. 369-399 31 p. (Woodhead Publishing Series in Biomaterials; no. 112).

    Research output: Chapter in Book/Report/Conference proceedingChapter

  • Cite this

    Mann, A., Campbell, D., & Tighe, B. J. (2016). The ageing ocular surface: challenges for biomaterials design and function. In T. V. Chirila, & D. G. Harkin (Eds.), Biomaterials and regenerative medicine in ophthalmology (2nd ed., pp. 17-43). (Woodhead Publishing Series in Biomaterials; No. 112). Woodhead. https://doi.org/10.1016/B978-0-08-100147-9.00002-X