The ageing pancreas

James E. Brown

doi:10.1177/1474651412446713

The ageing pancreas

James E. Brown

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

993 Downloads (Pure)

Abstract

Type 2 diabetes is historically associated with older adults, and glucose tolerance is known to decline with advancing age. During the course of natural ageing, changes in many peripheral tissues contribute to this deterioration of glucose homeostasis. Included in this process are changes to the structure and function of the pancreatic islets, which undergo deviation in endocrine responses to glycaemic challenge. Current knowledge about the changes seen in the ageing pancreas is reviewed here.

Original language	English
Pages (from-to)	141-145
Number of pages	5
Journal	British Journal of Diabetes and Vascular Disease
Volume	12
Issue number	3
DOIs	https://doi.org/10.1177/1474651412446713
Publication status	Published - May 2012

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

ageing
pancreatic islets
β-cells

Access to Document

10.1177/1474651412446713

The Ageing PancreasSubmitted manuscript, 246 KB

http://dvd.sagepub.com/content/12/3/141

Cite this

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AB - Type 2 diabetes is historically associated with older adults, and glucose tolerance is known to decline with advancing age. During the course of natural ageing, changes in many peripheral tissues contribute to this deterioration of glucose homeostasis. Included in this process are changes to the structure and function of the pancreatic islets, which undergo deviation in endocrine responses to glycaemic challenge. Current knowledge about the changes seen in the ageing pancreas is reviewed here.

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KW - β-cells

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The ageing pancreas

Abstract

UN SDGs

Keywords

Access to Document

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