The application of counter immunoelectrophoresis (CIE) in ocular protein studies. Part II: kinin activity in the lens wearing eye

Research output: Contribution to journalArticle

Abstract

The kinin family are a group of bioactive peptides that are closely involved in the modulation of vascular inflammation and local injury. We have demonstrated here, for the first time, a link between kinin activity and contact lens wear. Protein extracts from daily and extended wear etafilcon A, Group IV, Acuvue lenses (Vistakon), were analysed by counter immunoelectrophoresis. In this way, kinin activity associated with contact lens wear was detected. High molecular weight kininogen was used as the marker protein. In contrast, no kinin activity was detected in the non-lens wearing normal eye.
Original languageEnglish
Pages (from-to)81-88
Number of pages8
JournalContact Lens and Anterior Eye
Volume25
Issue number2
DOIs
Publication statusPublished - Jun 2002

Keywords

  • high molecular weight kininogen
  • Inflammatory mediators
  • contact lens
  • tears
  • counter immunoelectrophoresis

Fingerprint Dive into the research topics of 'The application of counter immunoelectrophoresis (CIE) in ocular protein studies. Part II: kinin activity in the lens wearing eye'. Together they form a unique fingerprint.

  • Cite this