The application of fixed hydrophobic patterns for confinement of aqueous solutions in proteomic microarrays

Y. Li; E.O. McKenna; W. Parkes; A.R. Pitt; A.J. Walton

doi:10.1063/1.3626037

The application of fixed hydrophobic patterns for confinement of aqueous solutions in proteomic microarrays

Y. Li^*
, E.O. McKenna
, W. Parkes
, A.R. Pitt
, A.J. Walton

^*Corresponding author for this work

College of Health and Life Sciences

University of Glasgow
University of Edinburgh

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

47 Downloads (Pure)

Abstract

A protein microarray hybridisation system has been implemented by employing patterned hydrophobic thin films on hydrophilic substrates as a means of confinement for aqueous samples. This approach has the ability to handle, and keep separate, small sample volumes of just a few microlitres. In addition, the system is more straightforward to use than the existing multi-well gasket solution. The paper describes the fabrication method and the system is demonstrated for a model protein microarray assay.

Original language	English
Article number	073703
Number of pages	3
Journal	Applied Physics Letters
Volume	99
Issue number	7
DOIs	https://doi.org/10.1063/1.3626037
Publication status	Published - 15 Aug 2011

Bibliographical note

Copyright © 2011 American Institute of Physics. This article may be downloaded for personal use only. Any other use requires prior permission of the author and the American Institute of Physics. The following article appeared in Appl. Phys. Lett. 99, 073703 (2011); and may be found at https://doi.org/10.1063/1.3626037

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10.1063/1.3626037

The application of fixed hydrophobic patterns for confinement of aqueous solutions in proteomic microarrays
Copyright © 2011 American Institute of Physics. This article may be downloaded for personal use only. Any other use requires prior permission of the author and the American Institute of Physics. The following article appeared in Appl. Phys. Lett. 99, 073703 (2011); and may be found at https://doi.org/10.1063/1.3626037
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AU - Walton, A.J.

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The application of fixed hydrophobic patterns for confinement of aqueous solutions in proteomic microarrays

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