The association between autism and schizophrenia spectrum disorders: A review of eight alternate models of co-occurrence

Katharine Chisholm, Ashleigh Lin, Ahmad Abu Akel, Stephen Wood

Research output: Contribution to journalReview article

Abstract

Although now believed to be two distinct disorders, autism spectrum disorders (ASD) and schizophrenia spectrum disorders (SSD) share multiple phenotypic similarities and risk factors, and have been reported to co-occur at elevated rates. In this narrative review, we give a brief overview of the phenomenological, genetic, environmental, and imaging evidence for the overlap between ASD and SSD, highlighting similarities and areas of distinction. We examine eight possible alternate models of explanation for the association and comorbidity between the disorders, and set out a research agenda to test these models. Understanding how and why these disorders co-occur has important implications for diagnosis, treatment, and prognosis, as well as for developing fundamental aetiological models of the disorders.
Original languageEnglish
Pages (from-to)173-183
JournalNeuroscience and Biobehavioral Reviews
Volume55
Early online date5 May 2015
DOIs
Publication statusPublished - 1 Aug 2015

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Schizophrenia
Comorbidity
Research
Autism Spectrum Disorder

Bibliographical note

© 2015, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/

Cite this

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title = "The association between autism and schizophrenia spectrum disorders: A review of eight alternate models of co-occurrence",
abstract = "Although now believed to be two distinct disorders, autism spectrum disorders (ASD) and schizophrenia spectrum disorders (SSD) share multiple phenotypic similarities and risk factors, and have been reported to co-occur at elevated rates. In this narrative review, we give a brief overview of the phenomenological, genetic, environmental, and imaging evidence for the overlap between ASD and SSD, highlighting similarities and areas of distinction. We examine eight possible alternate models of explanation for the association and comorbidity between the disorders, and set out a research agenda to test these models. Understanding how and why these disorders co-occur has important implications for diagnosis, treatment, and prognosis, as well as for developing fundamental aetiological models of the disorders.",
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The association between autism and schizophrenia spectrum disorders: A review of eight alternate models of co-occurrence. / Chisholm, Katharine; Lin, Ashleigh; Abu Akel, Ahmad; Wood, Stephen.

In: Neuroscience and Biobehavioral Reviews, Vol. 55, 01.08.2015, p. 173-183.

Research output: Contribution to journalReview article

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T1 - The association between autism and schizophrenia spectrum disorders: A review of eight alternate models of co-occurrence

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