The blood perfusion and NADH/FAD content combined analysis in patients with diabetes foot

Victor V. Dremin, Victor V. Sidorov, Alexander I. Krupatkin, Gagik R. Galstyan, Irina N. Novikova, Angelina I. Zherebtsova, Evgeny A. Zherebtsov, Andrey V. Dunaev, Zera N. Abdulvapova, Karina S. Litvinova, Ilya E. Rafailov, Sergei G. Sokolovski, Edik U. Rafailov

Research output: Chapter in Book/Report/Conference proceedingConference publication

Abstract

Skin blood microcirculation and the metabolism activity of tissue were examined on the patients with type 2 diabetes. Laser Doppler flowmetry (LDF) with 1064 nm laser light source and fluorescence spectroscopy (FS) with excitation light of 365 nm and 450 nm have been used to monitor the blood perfusion and the content of coenzymes NADH and FAD. Concluding, the proposed combined LDF and tissue FS approach allows to identify the significant violations in the blood microcirculation and metabolic activity for type 2 diabetes patients.

Original languageEnglish
Title of host publicationAdvanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XIV
EditorsTuan Vo-Dinh, Anita Mahadevan-Jansen, Warren S. Grundfest
Place of PublicationBellingham, WA (US)
PublisherSPIE
Number of pages7
ISBN (Print)978-1-6284-1932-0
DOIs
Publication statusPublished - 7 Mar 2016
EventAdvanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XIV - San Francisco, United States
Duration: 14 Feb 201616 Feb 2016

Publication series

NameSPIE Proceedings
PublisherSPIE
Volume9698
ISSN (Print)0277-786X
ISSN (Electronic)2410-9045
NameProgress in Biomedical Optics and Imaging
PublisherSpie
Number10
Volume17
ISSN (Print)1605-7422

Conference

ConferenceAdvanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XIV
CountryUnited States
CitySan Francisco
Period14/02/1616/02/16

Bibliographical note

Victor V. Dremin; Victor V. Sidorov; Alexander I. Krupatkin; Gagik R. Galstyan; Irina N. Novikova; Angelina I. Zherebtsova; Evgeny A. Zherebtsov; Andrey V. Dunaev; Zera N. Abdulvapova; Karina S. Litvinova; Ilya E. Rafailov; Sergei G. Sokolovski and Edik U. Rafailov; "The blood perfusion and NADH/FAD content combined analysis in patients with diabetes foot", Proc. SPIE 9698, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XIV, 969810 (March 7, 2016).

Copyright 2016. Society of Photo-Optical Instrumentation Engineers. One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.

DOI: http://dx.doi.org/10.1117/12.2212758

Keywords

  • diabetic foot syndrome
  • fluorescence spectroscopy
  • laser Doppler flowmetry
  • microcirculation
  • redox ratio

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