The case for aluminium as the neurotoxin in sporadic Alzheimer's disease

Paul S. Hodgkins, J.A. Blair, Richard A. Armstrong

Research output: Contribution to conferencePaper

Abstract

The flash-pattern evoked potential difference (F - P) in man increases with age (93 subjects), correlates with decreasing cognitive ability and when it exceeds a unique critical level the subject is clinically diagnosed as having Alzheimer's disease. Aluminium accumulates in the human brain with age, increases the F - P value close to the critical value in a dose dependent manner, and at such a rate that normal environmental exposure to aluminium accounts for all or nearly all the F - P increases in man. Aluminium neurotoxicity is therefore a major cause of sporadic Alzheimer's disease.
Original languageEnglish
Publication statusUnpublished - 1993
Event12th International Winter Workshop on Biochemical and Clinical Aspects of Pteridines - St. Christoph, Arlberg, Austria
Duration: 1 Feb 1993 → …

Workshop

Workshop12th International Winter Workshop on Biochemical and Clinical Aspects of Pteridines
CountryAustria
CitySt. Christoph, Arlberg
Period1/02/93 → …

Fingerprint

Neurotoxins
Aluminum
Alzheimer Disease
Aptitude
Environmental Exposure
Evoked Potentials
Brain

Bibliographical note

Abstract appearing in Pteridines 4:P99, 0933-4807

Keywords

  • flash-pattern evoked potential difference
  • cognitive ability
  • Alzheimer's disease
  • aluminium
  • brain
  • aluminium neurotoxicity

Cite this

Hodgkins, P. S., Blair, J. A., & Armstrong, R. A. (1993). The case for aluminium as the neurotoxin in sporadic Alzheimer's disease. Paper presented at 12th International Winter Workshop on Biochemical and Clinical Aspects of Pteridines, St. Christoph, Arlberg, Austria.
Hodgkins, Paul S. ; Blair, J.A. ; Armstrong, Richard A. / The case for aluminium as the neurotoxin in sporadic Alzheimer's disease. Paper presented at 12th International Winter Workshop on Biochemical and Clinical Aspects of Pteridines, St. Christoph, Arlberg, Austria.
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Hodgkins, PS, Blair, JA & Armstrong, RA 1993, 'The case for aluminium as the neurotoxin in sporadic Alzheimer's disease' Paper presented at 12th International Winter Workshop on Biochemical and Clinical Aspects of Pteridines, St. Christoph, Arlberg, Austria, 1/02/93, .

The case for aluminium as the neurotoxin in sporadic Alzheimer's disease. / Hodgkins, Paul S.; Blair, J.A.; Armstrong, Richard A.

1993. Paper presented at 12th International Winter Workshop on Biochemical and Clinical Aspects of Pteridines, St. Christoph, Arlberg, Austria.

Research output: Contribution to conferencePaper

TY - CONF

T1 - The case for aluminium as the neurotoxin in sporadic Alzheimer's disease

AU - Hodgkins, Paul S.

AU - Blair, J.A.

AU - Armstrong, Richard A.

N1 - Abstract appearing in Pteridines 4:P99, 0933-4807

PY - 1993

Y1 - 1993

N2 - The flash-pattern evoked potential difference (F - P) in man increases with age (93 subjects), correlates with decreasing cognitive ability and when it exceeds a unique critical level the subject is clinically diagnosed as having Alzheimer's disease. Aluminium accumulates in the human brain with age, increases the F - P value close to the critical value in a dose dependent manner, and at such a rate that normal environmental exposure to aluminium accounts for all or nearly all the F - P increases in man. Aluminium neurotoxicity is therefore a major cause of sporadic Alzheimer's disease.

AB - The flash-pattern evoked potential difference (F - P) in man increases with age (93 subjects), correlates with decreasing cognitive ability and when it exceeds a unique critical level the subject is clinically diagnosed as having Alzheimer's disease. Aluminium accumulates in the human brain with age, increases the F - P value close to the critical value in a dose dependent manner, and at such a rate that normal environmental exposure to aluminium accounts for all or nearly all the F - P increases in man. Aluminium neurotoxicity is therefore a major cause of sporadic Alzheimer's disease.

KW - flash-pattern evoked potential difference

KW - cognitive ability

KW - Alzheimer's disease

KW - aluminium

KW - brain

KW - aluminium neurotoxicity

M3 - Paper

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Hodgkins PS, Blair JA, Armstrong RA. The case for aluminium as the neurotoxin in sporadic Alzheimer's disease. 1993. Paper presented at 12th International Winter Workshop on Biochemical and Clinical Aspects of Pteridines, St. Christoph, Arlberg, Austria.