The flash-pattern evoked potential difference (F - P) in man increases with age (93 subjects), correlates with decreasing cognitive ability and when it exceeds a unique critical level the subject is clinically diagnosed as having Alzheimer's disease. Aluminium accumulates in the human brain with age, increases the F - P value close to the critical value in a dose dependent manner, and at such a rate that normal environmental exposure to aluminium accounts for all or nearly all the F - P increases in man. Aluminium neurotoxicity is therefore a major cause of sporadic Alzheimer's disease.
|Publication status||Unpublished - 1993|
|Event||12th International Winter Workshop on Biochemical and Clinical Aspects of Pteridines - St. Christoph, Arlberg, Austria|
Duration: 1 Feb 1993 → …
|Workshop||12th International Winter Workshop on Biochemical and Clinical Aspects of Pteridines|
|City||St. Christoph, Arlberg|
|Period||1/02/93 → …|
Bibliographical noteAbstract appearing in Pteridines 4:P99, 0933-4807
- flash-pattern evoked potential difference
- cognitive ability
- Alzheimer's disease
- aluminium neurotoxicity
Hodgkins, P. S., Blair, J. A., & Armstrong, R. A. (1993). The case for aluminium as the neurotoxin in sporadic Alzheimer's disease. Paper presented at 12th International Winter Workshop on Biochemical and Clinical Aspects of Pteridines, St. Christoph, Arlberg, Austria.