The case for aluminium as the neurotoxin in sporadic Alzheimer's disease

Paul S. Hodgkins, J.A. Blair, Richard A. Armstrong

Research output: Contribution to conferencePaper

Abstract

The flash-pattern evoked potential difference (F - P) in man increases with age (93 subjects), correlates with decreasing cognitive ability and when it exceeds a unique critical level the subject is clinically diagnosed as having Alzheimer's disease. Aluminium accumulates in the human brain with age, increases the F - P value close to the critical value in a dose dependent manner, and at such a rate that normal environmental exposure to aluminium accounts for all or nearly all the F - P increases in man. Aluminium neurotoxicity is therefore a major cause of sporadic Alzheimer's disease.
Original languageEnglish
Publication statusUnpublished - 1993
Event12th International Winter Workshop on Biochemical and Clinical Aspects of Pteridines - St. Christoph, Arlberg, Austria
Duration: 1 Feb 1993 → …

Workshop

Workshop12th International Winter Workshop on Biochemical and Clinical Aspects of Pteridines
CountryAustria
CitySt. Christoph, Arlberg
Period1/02/93 → …

Bibliographical note

Abstract appearing in Pteridines 4:P99, 0933-4807

Keywords

  • flash-pattern evoked potential difference
  • cognitive ability
  • Alzheimer's disease
  • aluminium
  • brain
  • aluminium neurotoxicity

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    Hodgkins, P. S., Blair, J. A., & Armstrong, R. A. (1993). The case for aluminium as the neurotoxin in sporadic Alzheimer's disease. Paper presented at 12th International Winter Workshop on Biochemical and Clinical Aspects of Pteridines, St. Christoph, Arlberg, Austria.