The case for aluminium as the neurotoxin in sporadic Alzheimer's disease

Paul S. Hodgkins; J.A. Blair; Richard A. Armstrong

The case for aluminium as the neurotoxin in sporadic Alzheimer's disease

Paul S. Hodgkins, J.A. Blair, Richard A. Armstrong

Research output: Unpublished contribution to conference › Unpublished Conference Paper › peer-review

Abstract

The flash-pattern evoked potential difference (F - P) in man increases with age (93 subjects), correlates with decreasing cognitive ability and when it exceeds a unique critical level the subject is clinically diagnosed as having Alzheimer's disease. Aluminium accumulates in the human brain with age, increases the F - P value close to the critical value in a dose dependent manner, and at such a rate that normal environmental exposure to aluminium accounts for all or nearly all the F - P increases in man. Aluminium neurotoxicity is therefore a major cause of sporadic Alzheimer's disease.

Original language	English
Publication status	Unpublished - 1993
Event	12th International Winter Workshop on Biochemical and Clinical Aspects of Pteridines - St. Christoph, Arlberg, Austria Duration: 1 Feb 1993 → …

Workshop

Workshop	12th International Winter Workshop on Biochemical and Clinical Aspects of Pteridines
Country/Territory	Austria
City	St. Christoph, Arlberg
Period	1/02/93 → …

Bibliographical note

Abstract appearing in Pteridines 4:P99, 0933-4807

Keywords

flash-pattern evoked potential difference
cognitive ability
Alzheimer's disease
aluminium
brain
aluminium neurotoxicity

Cite this

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title = "The case for aluminium as the neurotoxin in sporadic Alzheimer's disease",

abstract = "The flash-pattern evoked potential difference (F - P) in man increases with age (93 subjects), correlates with decreasing cognitive ability and when it exceeds a unique critical level the subject is clinically diagnosed as having Alzheimer's disease. Aluminium accumulates in the human brain with age, increases the F - P value close to the critical value in a dose dependent manner, and at such a rate that normal environmental exposure to aluminium accounts for all or nearly all the F - P increases in man. Aluminium neurotoxicity is therefore a major cause of sporadic Alzheimer's disease.",

keywords = "flash-pattern evoked potential difference, cognitive ability, Alzheimer's disease, aluminium, brain, aluminium neurotoxicity",

author = "Hodgkins, {Paul S.} and J.A. Blair and Armstrong, {Richard A.}",

note = "Abstract appearing in Pteridines 4:P99, 0933-4807; 12th International Winter Workshop on Biochemical and Clinical Aspects of Pteridines ; Conference date: 01-02-1993",

year = "1993",

language = "English",

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The case for aluminium as the neurotoxin in sporadic Alzheimer's disease. / Hodgkins, Paul S.; Blair, J.A.; Armstrong, Richard A.
1993. Paper presented at 12th International Winter Workshop on Biochemical and Clinical Aspects of Pteridines, St. Christoph, Arlberg, Austria.

Research output: Unpublished contribution to conference › Unpublished Conference Paper › peer-review

TY - CONF

T1 - The case for aluminium as the neurotoxin in sporadic Alzheimer's disease

AU - Hodgkins, Paul S.

AU - Blair, J.A.

AU - Armstrong, Richard A.

N1 - Abstract appearing in Pteridines 4:P99, 0933-4807

PY - 1993

Y1 - 1993

N2 - The flash-pattern evoked potential difference (F - P) in man increases with age (93 subjects), correlates with decreasing cognitive ability and when it exceeds a unique critical level the subject is clinically diagnosed as having Alzheimer's disease. Aluminium accumulates in the human brain with age, increases the F - P value close to the critical value in a dose dependent manner, and at such a rate that normal environmental exposure to aluminium accounts for all or nearly all the F - P increases in man. Aluminium neurotoxicity is therefore a major cause of sporadic Alzheimer's disease.

AB - The flash-pattern evoked potential difference (F - P) in man increases with age (93 subjects), correlates with decreasing cognitive ability and when it exceeds a unique critical level the subject is clinically diagnosed as having Alzheimer's disease. Aluminium accumulates in the human brain with age, increases the F - P value close to the critical value in a dose dependent manner, and at such a rate that normal environmental exposure to aluminium accounts for all or nearly all the F - P increases in man. Aluminium neurotoxicity is therefore a major cause of sporadic Alzheimer's disease.

KW - flash-pattern evoked potential difference

KW - cognitive ability

KW - Alzheimer's disease

KW - aluminium

KW - brain

KW - aluminium neurotoxicity

M3 - Unpublished Conference Paper

T2 - 12th International Winter Workshop on Biochemical and Clinical Aspects of Pteridines

Y2 - 1 February 1993

ER -

The case for aluminium as the neurotoxin in sporadic Alzheimer's disease

Abstract

Workshop

Bibliographical note

Keywords

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Cite this