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The Concise Guide to PHARMACOLOGY 2023/24: Ion channels

  • Stephen P H Alexander
  • , Alistair A Mathie
  • , John A Peters
  • , Emma L Veale
  • , Jörg Striessnig
  • , Eamonn Kelly
  • , Jane F Armstrong
  • , Elena Faccenda
  • , Simon D Harding
  • , Jamie A Davies
  • , Richard W Aldrich
  • , Bernard Attali
  • , Austin M Baggetta
  • , Elvir Becirovic
  • , Martin Biel
  • , Roslyn M Bill
  • , Ana I Caceres
  • , William A Catterall
  • , Alex C Conner
  • , Paul Davies
  • Katrien De Clerq, Markus Delling, Francesco Di Virgilio, Simonetta Falzoni, Stefanie Fenske, Anna Fortuny-Gomez, Samuel Fountain, Chandy George, Steve A N Goldstein, Christian Grimm, Stephan Grissmer, Kotdaji Ha, Verena Hammelmann, Israel Hanukoglu, Meiqin Hu, Ad P Ijzerman, Sairam V Jabba, Mike Jarvis, Anders A Jensen, Sven E Jordt, Leonard K Kaczmarek, Stephan Kellenberger, Charles Kennedy, Brian King, Philip Kitchen, Qiang Liu, Joseph W Lynch, Jessica Meades, Verena Mehlfeld, Annette Nicke, Stefan Offermanns, Edward Perez-Reyes, Leigh D Plant, Lachlan Rash, Dejian Ren, Mootaz M Salman, Werner Sieghart, Lucia G Sivilotti, Trevor G Smart, Terrance P Snutch, Jinbin Tian, James S Trimmer, Charlotte Van den Eynde, Joris Vriens, Aguan D Wei, Brenda T Winn, Heike Wulff, Haoxing Xu, Fan Yang, Wei Fang, Lixia Yue, Xiaoli Zhang, Michael Zhu
  • University of Nottingham Medical School
  • Suffolk University
  • University of Dundee
  • Medway School of Pharmacy, The Universities of Greenwich and Kent at Medway, Anson Building, Central Avenue Chatham Maritime Chatham, Kent ME4 4TB UK
  • Leopold-Franzens-Universität Innsbruck
  • University of Bristol
  • University of Edinburgh
  • Stanford University
  • Tel Aviv University
  • Northeastern University
  • Department of Radiology, Ludwig-Maximilian-University, Munich, Germany
  • Duke University
  • University of Washington, Seattle
  • University of Birmingham
  • Tufts University School of Medicine
  • Catholic University of Leuven Leuven Belgium
  • University of California San Francisco
  • Università degli Studi di Ferrara
  • University of East Anglia
  • Nanyang Technological University
  • University of California Irvine
  • Universität Ulm
  • Ariel University
  • Hangzhou Tourism Commission
  • Universiteit Leiden
  • University Illinois at Urbana-Champaign
  • Københavns Universitet
  • Yale University
  • Université de Lausanne
  • University of Strathclyde
  • University College London
  • University of Queensland
  • Max Planck Institute for Heart and Lung Research/JW Goethe University Bad Nauheim/Frankfurt Germany
  • University of Virginia
  • University of Pennsylvania
  • University of Oxford
  • Medical University of Vienna
  • University of British Columbia
  • University of Texas Houston
  • University of California Davis
  • University of Michigan
  • University of Connecticut

Research output: Contribution to journalArticlepeer-review

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Abstract

The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and over 6000 interactions with about 3900 ligands. There is an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (https://www.guidetopharmacology.org/), which provides more detailed views of target and ligand properties. Although the Concise Guide constitutes almost 500 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point‐in‐time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/10.1111/bph.16178. Ion channels are one of the six major pharmacological targets into which the Guide is divided, with the others being: G protein‐coupled receptors, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid‐2023, and supersedes data presented in the 2021/22, 2019/20, 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature and Standards Committee of the International Union of Basic and Clinical Pharmacology (NC‐IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.
Original languageEnglish
Pages (from-to)S145-S222
JournalBritish Journal of Pharmacology
Volume180
Issue numberSuppl.2
DOIs
Publication statusPublished - 20 Dec 2023

Bibliographical note

Copyright © 2023 The Authors. British Journal of Pharmacology published by John Wiley & Sons Ltd on behalf of The British Pharmacological Society. This is an open access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Keywords

  • Humans
  • Databases, Pharmaceutical
  • Ion Channels/chemistry
  • Ligands
  • Receptors, G-Protein-Coupled
  • Databases, Factual
  • Pharmacology

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