Abstract
The crystal structure of the neutral, distorted square planar copper(II) complex, viz. cis-[dichloro (N'-(2-benzyloxybenzylidene) pyridine-2-carboxamidrazone) copper(II)] (1) is reported which is the first well-characterized copper(II) complex of the series (space group C2/c, a = 18.414(5) Angstrom; b = 8.6510(10) Angstrom; c = 27.091(4) Angstrom; alpha = 90 degrees; beta = 109.800(17)degrees; gamma = 90 degrees; R-1 = 0.0331 wR(2) = 0.0852). The distortion from square planar geometry is thought to arise from the non-equivalent ligand donor set. The Cu-Cl bonds are equivalent with one of the Cl atoms making intermolecular contact at 2.6070 Angstrom with adjacent copper rendering a pseudo-square pyramidal geometry around copper. The complex is further characterized by UV/VIS spectroscopy, electrochemistry and magnetic susceptibility measurements. The in vitro antitumor activity of this complex and the parent ligand is determined against the human breast cancer cell-line MCF-7 which revealed that copper complexation renders a highly antiproliferative compound with IC50 value of 3 muM.
Original language | English |
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Pages (from-to) | 26-29 |
Number of pages | 4 |
Journal | Inorganic Chemistry Communications |
Volume | 4 |
Issue number | 1 |
DOIs | |
Publication status | Published - Jan 2001 |
Keywords
- carboxamidrazone
- copper complex
- antitumor activity
- breast cancer