The density of mature beta/A4 deposits is enhanced in Alzheimer's disease cases with pronounced congophilic angiopathy

Richard A. Armstrong, D. Myers, C.U.M. Smith

Research output: Contribution to conferencePoster

Abstract

The density of diffuse, primitive, classic and compact beta/A4 deposits was estimated in the cortex and hippocampus in Alzheimer's disease (AD) cases with pronounced congophilic angiopathy (CA). The total density of beta/A4 deposits in a brain region was similar in cases with and without CA. Significantly fewer diffuse deposits and more primitive/classic deposits were found in the cases with CA. The density of the primitive, classic and compact deposits were positively correlated in the cases without CA. However, no correlations were observed between the density of the mature subtypes and the diffuse deposits in these cases. In cases with CA, the density of the primitive deposits was positively correlated with the diffuse deposits but not with the classic deposits. The data suggest that the mature beta/A4 deposits are derived from the diffuse deposits and that the presence of pronounced CA enhances their formation.
Original languageEnglish
Publication statusUnpublished - 1993
EventBrain Research Association Conference - St Andrews (UK)
Duration: 1 Apr 1993 → …

Conference

ConferenceBrain Research Association Conference
CitySt Andrews (UK)
Period1/04/93 → …

Bibliographical note

Abstract appearing in Brain Res Assoc Abstr 10: P24.

Keywords

  • beta/A4 deposits
  • cortex
  • hippocampus
  • Alzheimer's disease
  • pronounced congophilic angiopathy
  • density
  • brain

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