The distribution of senile plaques, neurofibrillary tangles and beta/A4 deposits in the hippocampus in Alzheimer's disease

Richard A. Armstrong, D. Myers, C.U.M. Smith

Research output: Contribution to journalArticle

Abstract

The density of senile plaques (SP) and neurofibrillary tangles (NFT) was studied in Glees and Marsland stained sections of the hippocampus and parahippocampal gyrus (PHG) in 20 pateints with Alzheimer's disease. In addition, in six of the patients, the density of beta/A4 protein deposits, as revealed by immunohistochemistry and neurofibrillary changes demonstrated with the Gallyas stain, were studied in adjacent sections. The density of Glees SP and beta/A4 deposits was significantly greater in area CA1 of the hippocampus and in the subiculum than in the PHG. Hence, neurofibrillary degeneration appears to be a more important lesion than beta/A4 deposition in the hippocampus compared with the PHG. In addition, the detailed distribution of the lesions in the hippocampus could be explained if beta/A4/SP and NFT occur on the axon terminals and in the cell bodies respectively of the same neurons.
Original languageEnglish
Pages (from-to)87-94
Number of pages8
JournalNeuroscience Research Communications
Volume10
Issue number2
Publication statusPublished - 1992

Keywords

  • senile plaques
  • neurofibrillary tangles
  • hippocampus
  • parahippocampal gyrus
  • Alzheimer's disease
  • density
  • protein deposits
  • Gallyas stain

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