The effect of PEO length on the self-assembly of poly(ethylene oxide)−tetrapeptide conjugates prepared by “click” chemistry

Nadia Tzokova, Christine M. Fernyhough, Michael F. Butler, Steve P. Armes, Anthony J. Ryan, Paul Topham, Dave J. Adams

Research output: Contribution to journalArticle

Abstract

Two series of poly(ethylene oxide)-tetrapeptide conjugates have been prepared using a “Click” reaction between an alkyne-modified tetra(phenylalanine) or tetra(valine) and various azide-terminated poly(ethylene oxide) (PEO) oligomers. Three different PEO precursors were used to prepare these conjugates, with number-average molecular weights of 350, 1200, and 1800 Da. Assembly of mPEO-F4-OEt and mPEO-V4-OEt conjugates was achieved by dialysis of a THF solution of the conjugate against water or by direct aqueous rehydration of a thin film. The PEO length has a profound effect on the outcome of the self-assembly, with the F4 conjugates giving rise to nanotubes, fibers, and wormlike micelles, respectively, as the length of the PEO block is increased. For the V4 series, the propensity to form ß-sheets dominates, and hence, the self-assembled structures are reminiscent of those formed by peptides alone, even at the longer PEO lengths. Thus, this systematic study demonstrates that the self-assembly of PEO-peptides depends on both the nature of the peptides and the relative PEO block length.
LanguageEnglish
Pages11082-11089
Number of pages8
JournalLangmuir
Volume25
Issue number18
DOIs
Publication statusPublished - 17 Aug 2009

Fingerprint

ethylene oxide
Polyethylene oxides
Self assembly
self assembly
chemistry
peptides
Peptides
dialysis
phenylalanine
alkynes
oligomers
molecular weight
nanotubes
micelles
assembly
Alkynes
Dialysis
Azides
Valine
Micelles

Keywords

  • chemistry
  • 'click' chemistry
  • poly(ethylene oxide)
  • PEO

Cite this

Tzokova, N., Fernyhough, C. M., Butler, M. F., Armes, S. P., Ryan, A. J., Topham, P., & Adams, D. J. (2009). The effect of PEO length on the self-assembly of poly(ethylene oxide)−tetrapeptide conjugates prepared by “click” chemistry. Langmuir, 25(18), 11082-11089. https://doi.org/10.1021/la901413n
Tzokova, Nadia ; Fernyhough, Christine M. ; Butler, Michael F. ; Armes, Steve P. ; Ryan, Anthony J. ; Topham, Paul ; Adams, Dave J. / The effect of PEO length on the self-assembly of poly(ethylene oxide)−tetrapeptide conjugates prepared by “click” chemistry. In: Langmuir. 2009 ; Vol. 25, No. 18. pp. 11082-11089.
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The effect of PEO length on the self-assembly of poly(ethylene oxide)−tetrapeptide conjugates prepared by “click” chemistry. / Tzokova, Nadia; Fernyhough, Christine M.; Butler, Michael F.; Armes, Steve P.; Ryan, Anthony J.; Topham, Paul; Adams, Dave J.

In: Langmuir, Vol. 25, No. 18, 17.08.2009, p. 11082-11089.

Research output: Contribution to journalArticle

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