The effect of pH on PAMAM dendrimer-siRNA complexation: endosomal considerations as determined by molecular dynamics simulation

Medicine & Life Sciences

• Amines 13%
• Buffers 11%
• Dendrimers 88%
• Endosomes 29%
• Gene Transfer Techniques 16%
• Genes 26%
• In Vitro Techniques 5%
• Molecular Dynamics Simulation 72%
• Molecular Weight 10%
• Nucleic Acids 12%
• Poly(amidoamine) 100%
• Polymers 11%
• Porifera 14%
• Product Packaging 15%
• Protons 13%
• Small Interfering RNA 54%
• Transfection 11%

Chemistry

• Acid 4%
• Buffer Solution 8%
• Complexation 49%
• Dendrimer 12%
• Environment 22%
• Free Energy of Binding 16%
• Mixture 5%
• Molecular Dynamics 47%
• pH Value 27%
• Primary Amine 12%
• Proton 8%
• Secondary Amine 12%
• Silencing RNA 16%
• Simulation 40%
• Tertiary Amine 13%
• Time 4%